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220805-22-1

220805-22-1 Structure

220805-22-1 Structure
IdentificationBack Directory
[Name]

NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE
[CAS]

220805-22-1
[Synonyms]

ADMA
ADMA 2HCL
ADMA DIHYDROCHLORIDE
asym-Dimethylarginine
asym-Dimethylarginine, ADMA
NG,NG-DIMETHYLARGININE, DIHYDROCHLORIDE
NG,NG-dimethyl-L-Arginine (hydrochloride)
NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE
NG,NG-Dimethylarginine Dihydrochloride Solution, 100ppm
N5-[(DIMETHYLAMINO)IMINOMETHYL]-L-ORNITHINE, DIHYDROCHLORIDE
(S)-2-aMino-5-(3,3-diMethylguanidino)pentanoic acid dihydrochloride
[Molecular Formula]

C8H20Cl2N4O2
[MDL Number]

MFCD00270857
[MOL File]

220805-22-1.mol
[Molecular Weight]

275.18
Chemical PropertiesBack Directory
[Appearance]

White Crystalline Solid
[Melting point ]

202-204OC
[storage temp. ]

Hygroscopic, -20°C Freezer, Under Inert Atmosphere
[solubility ]

DMSO (Slightly, Heated, Sonicated), Methanol (Slightly), Water (Slightly)
[form ]

White to off-white crystalline solid.
[color ]

White to Off-White
[Water Solubility ]

Soluble in water (100 mM)
[Stability:]

Store at 0-5°C; Moisture Sensitive; Hygroscopic
[CAS DataBase Reference]

220805-22-1
Hazard InformationBack Directory
[Chemical Properties]

White Crystalline Solid
[Uses]

A potent inhibitor of NO synthase of adrenal glands, brain, and vascular endothelial cells
[General Description]

NG,NG-Dimethylarginine dihydrochloride is a methylated arginine derivative, which is produced by the liver. It is linked to liver cirrhosis, alcoholic hepatitis and acute liver failure (ALF).
[Biological Activity]

ng,ng-dimethyl-l-arginine is an endogenous nitric oxide synthase inhibitor.nitric oxide (no) that is synthesised from l-arginine contributes to the regulation of blood pressure and to host defence.
[Biochem/physiol Actions]

Reversible inhibitor of nitric oxide synthetase in vivo and in vitro.
[in vitro]

ng,ng-dimethyl-l-arginine (adma) was found to be able to inhibit macrophage and vascular no synthase. when added to a cytosolic preparation of macrophage no synthase, adma could cause dose-dependent inhibition of no formation. in the presence of added arginine, adma could inhibited no synthesis and the inhibitory effects of adma were prevented by addition of l-arginine so that the rate of no synthesis did not significantly differ from control values [1].
[in vivo]

animal study showed that the injection of 1-30 mg/kg adma into 3 anaesthetised guineapigs could cause dose-dependent increases in mean arterial blood pressure. moreover, during continuous infusion of adma, which caused plasma adma concentrations to rise approximately 9-fold, the systolic blood pressure was raised by nearly 15 % [1].
[storage]

Store at -20°C
[References]

[1] vallance, p. ,leone, a.,calver, a., et al. accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. lancet 339, 572-575 (1992).
Safety DataBack Directory
[WGK Germany ]

3
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