| Identification | Back Directory | [Name]
2,6-Methano-3-benzazocin-10-ol, 1,2,3,4,5,6-hexahydro-6,11,11-trimethyl-3-[(2S)-2-(phenylmethoxy)propyl]-, hydrochloride (1:1), (2R,6S)- | [CAS]
221018-88-8 | [Synonyms]
BIII-890
Crobenetine hydrochloride
2,6-Methano-3-benzazocin-10-ol, 1,2,3,4,5,6-hexahydro-6,11,11-trimethyl-3-[(2S)-2-(phenylmethoxy)propyl]-, hydrochloride (1:1), (2R,6S)- | [Molecular Formula]
C25H34ClNO2 | [MOL File]
221018-88-8.mol | [Molecular Weight]
416 |
| Hazard Information | Back Directory | [Uses]
Crobenetine hydrochloride (BIII-890 hydrochloride) is the hydrochloride form of Crobenetine (HY-16923). Crobenetine hydrochloride is a selective inhibitor for Na+ channel. Crobenetine hydrochloride displaces 3HBTX from site 2 of the Na+ channel (IC50=49 nM) in rat brain synaptosomes, exhibits only low binding affinity for other receptors and ion channels. Crobenetine hydrochloride protects brain tissue from the deleterious effects of focal cerebral ischemia in rodents[1]. | [References]
[1] A J Carter, et al. Potent blockade of sodium channels and protection of brain tissue from ischemia by BIII 890 CL. Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4944-9. DOI:10.1073/pnas.040577097 |
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