ChemicalBook--->CAS DataBase List--->22116-33-2

22116-33-2

22116-33-2 Structure

22116-33-2 Structure
IdentificationMore
[Name]

2-(4-FLUOROBENZYLAMINO)ETHANOL
[CAS]

22116-33-2
[Synonyms]

CHEMBRDG-BB 4004526
2-(4-FLUOROBENZYLAMINO)ETHANOL
2-(4-Fluorobenzyl)-Ethanolamino
2-(4-FLUOROBENZYLAMINO)ETHANOL,98%
2-[(4-fluorophenyl)methylamino]ethanol
Ethanol-2-(4-(fluorophenyl)methyl)amine
Ethanol, 2-[[(4-fluorophenyl)Methyl]aMino]-
2-[(4-fluorobenzyl)amino]ethanol(SALTDATA: FREE)
[Molecular Formula]

C9H12FNO
[MDL Number]

MFCD04560903
[Molecular Weight]

169.2
[MOL File]

22116-33-2.mol
Chemical PropertiesBack Directory
[Boiling point ]

95-98 °C(Press: 3 Torr)
[density ]

1.1358 g/cm3
[storage temp. ]

Sealed in dry,2-8°C
[pka]

14.75±0.10(Predicted)
[CAS DataBase Reference]

22116-33-2(CAS DataBase Reference)
Questions And AnswerBack Directory
[Uses]

2-[(4-Fluorobenzyl)amino]ethanol is used in preparation of (Fluorobenzyl)aminomethylmorpholine salt and its application in preparation of mosapride citrate.
Safety DataBack Directory
[Hazard Codes ]

T
[Risk Statements ]

25
[Safety Statements ]

45
[HazardClass ]

IRRITANT
Hazard InformationBack Directory
[Application]

2-(4-FLUOROBENZYLAMINO)ETHANOL can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
[Synthesis]

Synthesis_22116-33-2
P-fluorobenzaldehyde (24.8 g, 0.2 mol) and 2-aminoethanol (15.3 g, 0.25 mol) were added to a reaction flask containing methanol (250 ml), heated to reflux, and kept at 65 ?? C for 4 h.The temperature was lowered, sodium borohydride (9.2 g 0.24 mol) was added, and the reaction was stirred, the reaction was completed, filtered, and concentrated.The fraction was collected to give 2-(4-fluorobenzylamino)ethanol as a colorless oily liquid (yield: 90.2%, purity 98.7%).
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