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22200-69-7

22200-69-7 Structure

22200-69-7 Structure
IdentificationBack Directory
[Name]

Dinaphtho[2,3-b:2',3'-d]thiophene-5,7,12,13-tetrone
[CAS]

22200-69-7
[Synonyms]

Seriniquinone
Dinaphtho[2,3-b:2',3'-d]thiophene-5,7,12,13-tetrone
[Molecular Formula]

C20H8O4S
[MOL File]

22200-69-7.mol
[Molecular Weight]

344.34
Chemical PropertiesBack Directory
[Melting point ]

288 °C
[Boiling point ]

612.3±54.0 °C(Predicted)
[density ]

1.578±0.06 g/cm3(Predicted)
[storage temp. ]

-20°C
[solubility ]

Soluble in DMSO (up to 15 mg/ml with warming) or in DMF (up to 15 mg/ml)
[form ]

solid
[color ]

Orange
[Stability:]

Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 3 months.
Hazard InformationBack Directory
[Description]

Seriniquinone (22200-69-7) is a new natural product isolated from a marine bacterium of the genus Serinicoccus. Displays selective toxicity against a distinct set of cell lines (within the NCI 60 panel) predominantly melanoma. Upon cellular treatment, seriniquinone was found to localize in the endoplasmic reticulum. Within 3 hours cells underwent autophagy followed by death via a caspase-9 apoptotic pathway. The target of seriniquinone was identified as the small protein, dermcidin, as determined using an immunoaffinity approach.1
[Uses]

Seriniquinone is a marine natural product, that displays potent cytotoxicity and selectivity against melanoma cancer cells.
[References]

1) Trzoss?et al. (2014),?Seriniquinone, a selective anticancer agent, induces cell death by autophagocytosis, targeting the cancer-protective protein dermcidin; Proc. Natl. Acad. Sci. USA,?111?14687
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Tags:22200-69-7 Related Product Information
6754-58-1 781661-94-7 19545-26-7 104196-68-1

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