Identification | Back Directory | [Name]
Dinaphtho[2,3-b:2',3'-d]thiophene-5,7,12,13-tetrone | [CAS]
22200-69-7 | [Synonyms]
Seriniquinone Dinaphtho[2,3-b:2',3'-d]thiophene-5,7,12,13-tetrone | [Molecular Formula]
C20H8O4S | [MOL File]
22200-69-7.mol | [Molecular Weight]
344.34 |
Chemical Properties | Back Directory | [Melting point ]
288 °C | [Boiling point ]
612.3±54.0 °C(Predicted) | [density ]
1.578±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Soluble in DMSO (up to 15 mg/ml with warming) or in DMF (up to 15 mg/ml) | [form ]
solid | [color ]
Orange | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 3 months. |
Hazard Information | Back Directory | [Description]
Seriniquinone (22200-69-7) is a new natural product isolated from a marine bacterium of the genus Serinicoccus. Displays selective toxicity against a distinct set of cell lines (within the NCI 60 panel) predominantly melanoma. Upon cellular treatment, seriniquinone was found to localize in the endoplasmic reticulum. Within 3 hours cells underwent autophagy followed by death via a caspase-9 apoptotic pathway. The target of seriniquinone was identified as the small protein, dermcidin, as determined using an immunoaffinity approach.1 | [Uses]
Seriniquinone is a marine natural product, that displays potent cytotoxicity and selectivity against melanoma cancer cells. | [References]
1) Trzoss?et al. (2014),?Seriniquinone, a selective anticancer agent, induces cell death by autophagocytosis, targeting the cancer-protective protein dermcidin; Proc. Natl. Acad. Sci. USA,?111?14687 |
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Company Name: |
Merck KGaA
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Tel: |
21-20338288 |
Website: |
www.sigmaaldrich.cn |
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