| Identification | Back Directory | [Name]
LYN PEPTIDE INHIBITOR | [CAS]
222018-18-0 | [Synonyms]
LYN PEPTIDE INHIBITOR
M.W. 2370.91 C115H184N30O24
L-Prolinamide, N-(1-oxooctadecyl)-L-tyrosylglycyl-L-tyrosyl-L-arginyl-L-leucyl-L-arginyl-L-arginyl-L-lysyl-L-tryptophyl-L-α-glutamyl-L-α-glutamyl-L-lysyl-L-isoleucyl-L-prolyl-L-asparaginyl- | [Molecular Formula]
C115H184N30O24 | [MDL Number]
MFCD07785355 | [MOL File]
222018-18-0.mol | [Molecular Weight]
2370.88 |
| Hazard Information | Back Directory | [Uses]
Lyn peptide inhibitor is a potent and cell-permeable inhibitor of Lyn-coupled IL-5 receptor signaling pathway, while keeping other signals intact. Lyn peptide inhibitor blocks Lyn activation and inhibits the binding of Lyn tyrosine kinase to?βc subunit of IL-3/GM-CSF/IL-5 receptors. Lyn peptide inhibitor can be used for study of ?asthma, allergic, and other eosinophilic disorders[1]. | [IC 50]
IL-5; IL-3 | [References]
[1] T Adachi, et al. The mapping of the Lyn kinase binding site of the common beta subunit of IL-3/granulocyte-macrophage colony-stimulating factor/IL-5 receptor. J Immunol. 1999 Feb 1;162(3):1496-501. PMID:9973406
[2] T Adachi, et al. A novel Lyn-binding peptide inhibitor blocks eosinophil differentiation, survival, and airway eosinophilic inflammation. J Immunol. 1999 Jul 15;163(2):939-46. PMID:10395690 |
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