| Identification | Back Directory | [Name]
2-Propenamide, N-[4-[1-(3-aminobenzoyl)-4-piperidinyl]butyl]-3-(3-pyridinyl)-, (2E)- | [CAS]
2222981-61-3 | [Synonyms]
Nampt-IN-15
(E)-N-(4-(1-(3-Aminobenzoyl)piperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide
2-Propenamide, N-[4-[1-(3-aminobenzoyl)-4-piperidinyl]butyl]-3-(3-pyridinyl)-, (2E)- | [Molecular Formula]
C24H30N4O2 | [MOL File]
2222981-61-3.mol | [Molecular Weight]
406.52 |
| Chemical Properties | Back Directory | [Boiling point ]
691.0±55.0 °C(predicted) | [density ]
1.166±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
14.12±0.46(predicted) |
| Hazard Information | Back Directory | [Uses]
Nampt-IN-15 (Example 3) is an Nampt inhibitor. Nampt-IN-15 shows cytotoxicity against BxPC-3, HepG2, L540cy and MOLM-13, with IC50s of 38.5 nM, 8 nM, 8.5 nM, 7 nM respectively[1]. | [References]
[1] Christopher Scott NEUMANN, et al. Targeted delivery of nicotinamide adenine dinucleotide salvage pathway inhibitors. Patent. WO2018075600 |
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