| Identification | Back Directory | [Name]
3,4-Pyrrolidinediol, 2-(4-amino-5H-pyrrolo3,2-dpyrimidin-7-yl)-5-(hydroxymethyl)-, monohydrochloride, (2S,3S,4R,5R)- | [CAS]
222631-44-9 | [Synonyms]
BCX 4430
Galidesivir)
Galidesivir HCl
BCX-4430
(BCX4430
BCX4430;GALIDESIVIR
BCX 4430 hydrochloride
Galidesivir hydrochloride
Immucillin-A hydrochloride
GALIDESIVIR HYDROCHLORIDE (BCX 4430 HYDROCHLORIDE)
(2S,3S,4R,5R)-2-(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)-3,4-pyrrolidinediol monohydrochloride
3,4-Pyrrolidinediol, 2-(4-amino-5H-pyrrolo3,2-dpyrimidin-7-yl)-5-(hydroxymethyl)-, monohydrochloride, (2S,3S,4R,5R)-
3,4-Pyrrolidinediol,2-(4-aMino-5H-pyrrolo[3,2-d]pyriMidin-7-yl)-5-(hydroxyMethyl)-, hydrochloride(1:1), (2S,3S,4R,5R)- | [Molecular Formula]
C11H16ClN5O3 | [MOL File]
222631-44-9.mol | [Molecular Weight]
301.73 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
H2O: 2 mg/mL, clear | [form ]
Solid | [color ]
White to off-white | [Water Solubility ]
Water : ≥ 41 mg/mL (135.88 mM) |
| Hazard Information | Back Directory | [Uses]
BCX 4430 is an antiviral drug, an adenosine analog). It is developed by BioCryst Pharmaceuticals with funding from NIAID, originally intended as a treatment for Hepatitis C, but subsequently developed as a potential treatment for deadly filovirus infections such as Ebola virus disease and Marburg virus disease. | [in vivo]
Galidesivir (BCX4430) hydrochloride is active after intramuscular, intraperitoneal, and oral administration in a variety of experimental infections. In nonclinical studies involving lethal infections with Ebola virus, Marburg virus, Rift Valley fever virus, and Yellow Fever virus, Galidesivir hydrochloride has demonstrated pronounced efficacy[1].
Galidesivir hydrochloride (4 mg/kg; i.p.; twice daily for 7 days) is effectively in a hamster model of yellow fever (YF)[4]. | Animal Model: | Female Syrian golden hamsters (hamsters infected with YF virus)[4] | | Dosage: | 4 mg/kg of body weight | | Administration: | I.p.; twice daily for 7 days | | Result: | Significantly improved the survival of hamsters infected with YFV. |
| [storage]
Store at -20°C |
|
| Company Name: |
LETOPHARM LIMITED
|
| Telephone: |
+86-21-5821 5861 |
| Website: |
www.letopharm.com |
| Company Name: |
SPIRO PHARMA
|
| Telephone: |
|
| Website: |
www.spiropharma.com.cn |
| Company Name: |
NewCan Biotech Limited
|
| Telephone: |
+86-571-86912261 19975279805 |
| Website: |
https://www.newcanbio.com/ |
| Company Name: |
AFINE CHEMICALS LIMITED
|
| Telephone: |
+86-571-85134551 +86-18958018566 |
| Website: |
www.afinechem.com/index.html |
| Company Name: |
ChemeGen
|
| Telephone: |
18818260767 |
| Website: |
https://www.chemegen.com |
| Company Name: |
NewCan Biotech Limited
|
| Telephone: |
+86-0571-86912261 +86-15658003402 |
| Website: |
https://www.newcanbio.com/ |
|