| Identification | Back Directory | [Name]
(Z)-1-[2-CHLORO-2-(2,4-DICHLOROPHENYL)ETHENYL]-1H-1,2,4-TRIAZOLE HYDROCHLORIDE | [CAS]
2227372-56-5 | [Synonyms]
LORECLEZOLE HYDROCHLORIDE
(Z)-1-[2-CHLORO-2-(2,4-DICHLOROPHENYL)ETHENYL]-1H-1,2,4-TRIAZOLE HYDROCHLORIDE | [Molecular Formula]
C10H7Cl4N3 | [MDL Number]
MFCD03453292 | [MOL File]
2227372-56-5.mol | [Molecular Weight]
310.99 |
| Hazard Information | Back Directory | [Uses]
Loreclezole Hydrochloride is the hydrochoride salt of Loreclezole, which provides γ-aminobutyric acid type A receptors modulation. | [in vivo]
Loreclezole (10, 25, 50 or 75 mg/kg, i.p. 60 min before measurement of seizure threshold ) results in a dosedependent rise in seizure threshold as measured by the dose of pentylenetetrazolrequired to produce a convulsion 60 min later. Loreclezole also has the least effect on loss of muscle tone as measured by the "pull-up" test[3]. | Animal Model: | Adult male Lister Hooded rats[3]. | | Dosage: | 10, 25, 50 or 75 mg/kg. | | Administration: | IP, 60 min before measurement of seizure threshold. | | Result: | Resulted in a dosedependent rise in seizure threshold as measured by the dose of pentylenetetrazolrequired to produce a convulsion 60 min later. |
| [storage]
Desiccate at -20°C |
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