| Identification | Back Directory | [Name]
Azadibenzocyclooctyne-PEG1-N-hydroxysuccinimidyl ester | [CAS]
2228857-34-7 | [Synonyms]
DBCO-PEG1-NHS Ester
DBCO-NH-PEG1-CH2CH2COONHS ester
Azadibenzocyclooctyne-PEG1-N-hydroxysuccinimidyl ester | [Molecular Formula]
C28H27N3O7 | [MDL Number]
MFCD31615436 | [MOL File]
2228857-34-7.mol | [Molecular Weight]
517.54 |
| Chemical Properties | Back Directory | [density ]
1.39±0.1 g/cm3(Predicted) | [solubility ]
Soluble in DMSO, DCM, DMF | [form ]
Solid | [pka]
15.12±0.46(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Description]
DBCO-PEG1-NHS Ester is a PEG containing molecule containing an NHS ester moiety that can react specifically and efficiently with primary amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic condition to form a covalent bond. DBCO is commonly used for copper-free Click Chemistry reactions. | [Uses]
DBCO-PEG1-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-PEG1-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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