| Identification | Back Directory | [Name]
2H-1-Benzopyran-6-sulfonamide, N-cyclobutyl-N-(4-ethylphenyl)-3,4-dihydro-4-hydroxy-2-(tetrahydro-2H-pyran-4-yl)- | [CAS]
2230779-18-5 | [Synonyms]
RORγt inverse agonist 23
2H-1-Benzopyran-6-sulfonamide, N-cyclobutyl-N-(4-ethylphenyl)-3,4-dihydro-4-hydroxy-2-(tetrahydro-2H-pyran-4-yl)- | [Molecular Formula]
C26H33NO5S | [MOL File]
2230779-18-5.mol | [Molecular Weight]
471.61 |
| Chemical Properties | Back Directory | [Boiling point ]
641.7±65.0 °C(Predicted) | [density ]
1.299±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, away from moisture | [solubility ]
DMSO : ≥ 100 mg/mL (212.04 mM) | [form ]
Solid | [pka]
13.63±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
RORγt inverse agonist 23 is a potent, selective, and orally available novel retinoic acid receptor-related orphan receptor γt inverse agonist. | [References]
[1] Chen L, et al. Discovery of Chromane-6-Sulfonamide Derivative as a Potent, Selective, and Orally Available Novel Retinoic Acid Receptor-Related Orphan Receptor γt Inverse Agonist. J Med Chem. 2021 Nov 11;64(21):16106-16131. DOI:10.1021/acs.jmedchem.1c01436 |
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