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2237942-08-2

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2237942-08-2 Structure

2237942-08-2 Structure
IdentificationBack Directory
[Name]

MC180295
[CAS]

2237942-08-2
[Synonyms]

MC180295
(rel)-MC180295
MC-180295;MC 180295
MC180295 ((REL)-MC180295)
Methanone, [4-amino-2-[(1R,2R,4S)-bicyclo[2.2.1]hept-2-ylamino]-5-thiazolyl](2-nitrophenyl)-, rel-
[Molecular Formula]

C17H18N4O3S
[MDL Number]

MFCD31924820
[MOL File]

2237942-08-2.mol
[Molecular Weight]

358.41
Chemical PropertiesBack Directory
[Boiling point ]

623.8±65.0 °C(Predicted)
[density ]

1.462±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : 100 mg/mL (279.01 mM)
[form ]

Solid
[pka]

2.40±0.10(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

MC180295 can be useful in combination therapy of BET proteolysis targeting chimeric mol. with CDK9 inhibitor against human multiple myeloma cells.
[Biological Activity]

MC180295 ((rel)-MC180295) is a novel potent and selective CDK9 inhibitor with IC50 of 5 nM, at least 22-fold selective for CDK9 over other CDKs.
[in vivo]

MC180295 has antitumor and immunoallergic activity.

[target]

TargetValue
CDK9-Cyclin T1
(Cell-free assay)		 5 nM
CDK4-Cyclin D
(Cell-free assay)		 112 nM
CDK1-Cyclin B
(Cell-free assay)		 138 nM
CDK5-P35 < br/> (Cell-free assay) 159 nM
CDK5-P25
(Cell-free assay)		 186 nM
[IC 50]

CDK9- Cyclin T1: 5 nM (IC50); CDK4-Cyclin D: 112 nM (IC50); CDK1-Cyclin B: 138 nM (IC50); cdk5-p35: 159 nM (IC50); cdk5-p25: 186 nM (IC50); cdk2-cyclin A: 233 nM (IC50); cdk2-cyclin E: 367 nM (IC50); CDK3-Cyclin E: 399 nM (IC50); CDK7-CycH/MAT1: 555 nM (IC50); cdk6-cyclin D3: 712 nM (IC50)
[storage]

Store at -20°C
Spectrum DetailBack Directory
[Spectrum Detail]

MC180295(2237942-08-2)1HNMR
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