| Identification | Back Directory | [Name]
MC180295 | [CAS]
2237942-08-2 | [Synonyms]
MC180295
(rel)-MC180295
MC-180295;MC 180295
MC180295 ((REL)-MC180295)
Methanone, [4-amino-2-[(1R,2R,4S)-bicyclo[2.2.1]hept-2-ylamino]-5-thiazolyl](2-nitrophenyl)-, rel- | [Molecular Formula]
C17H18N4O3S | [MDL Number]
MFCD31924820 | [MOL File]
2237942-08-2.mol | [Molecular Weight]
358.41 |
| Chemical Properties | Back Directory | [Boiling point ]
623.8±65.0 °C(Predicted) | [density ]
1.462±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 100 mg/mL (279.01 mM) | [form ]
Solid | [pka]
2.40±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
MC180295 can be useful in combination therapy of BET proteolysis targeting chimeric mol. with CDK9 inhibitor against human multiple myeloma cells. | [Biological Activity]
MC180295 ((rel)-MC180295) is a novel potent and selective CDK9 inhibitor with IC50 of 5 nM, at least 22-fold selective for CDK9 over other CDKs. | [in vivo]
MC180295 has antitumor and immunoallergic activity. | [target]
| Target | Value | CDK9-Cyclin T1
(Cell-free assay) | 5 nM | CDK4-Cyclin D
(Cell-free assay) | 112 nM | CDK1-Cyclin B
(Cell-free assay) | 138 nM | | CDK5-P35 < br/> (Cell-free assay) | 159 nM | CDK5-P25
(Cell-free assay) | 186 nM |
| [IC 50]
CDK9- Cyclin T1: 5 nM (IC50); CDK4-Cyclin D: 112 nM (IC50); CDK1-Cyclin B: 138 nM (IC50); cdk5-p35: 159 nM (IC50); cdk5-p25: 186 nM (IC50); cdk2-cyclin A: 233 nM (IC50); cdk2-cyclin E: 367 nM (IC50); CDK3-Cyclin E: 399 nM (IC50); CDK7-CycH/MAT1: 555 nM (IC50); cdk6-cyclin D3: 712 nM (IC50) | [storage]
Store at -20°C |
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
|