2245073-05-4

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2245073-05-4 Structure

Identification	Back Directory
[Name] INDEX NAME NOT YET ASSIGNED
[CAS] 2245073-05-4
[Synonyms]
[Molecular Formula] C112H184N40O25S3
[MOL File] 2245073-05-4.mol
[Molecular Weight] 2587.14

Hazard Information	Back Directory
[Uses] ELA-21 (human) is an apelin receptor agonist with a pKi of 8.52. ELA-21 (human) completely inhibits Forskolin-induced cAMP production and stimulates β-arrestin recruitment with subnanomolar potencies. ELA-21 (human) is an agonist in G-protein-dependent and -independent pathways[1].
[References] [1] Peiran Yang, et al. Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension. Circulation. 2017 Mar 21;135(12):1160-1173. DOI:10.1161/CIRCULATIONAHA.116.023218

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