| Identification | Back Directory | [Name]
2,6-Diazaspiro[3.3]heptane, 2-[6-chloro-1-[(4-fluoro-3,5-dimethylphenyl)methyl]-4-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]- | [CAS]
2245237-53-8 | [Synonyms]
VUBI1
SOS1 activator 1
2,6-Diazaspiro[3.3]heptane, 2-[6-chloro-1-[(4-fluoro-3,5-dimethylphenyl)methyl]-4-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]- | [Molecular Formula]
C26H32ClFN6 | [MOL File]
2245237-53-8.mol | [Molecular Weight]
483.02 |
| Chemical Properties | Back Directory | [Boiling point ]
669.4±65.0 °C(Predicted) | [density ]
1.39±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
9.68±0.20(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
SOS1 activator 1 (Compound 64) is a potent activator of SOS1-mediated nucleotide exchange with a Kd of 44 nM. SOS1 is a guanine nucleotide exchange factor that catalyzes the exchange of GDP for GTP on RAS[1]. | [References]
[1] Timothy R Hodges, et al. Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS. J Med Chem. 2018 Oct 11;61(19):8875-8894. DOI:10.1021/acs.jmedchem.8b01108 |
|
|