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2247481-08-7

2247481-08-7 Structure

2247481-08-7 Structure
IdentificationBack Directory
[Name]

2H-Pyran-4-carbonitrile, 4-[[[4-[5-chloro-2-[[trans-4-[[(1R)-2-methoxy-1-methylethyl]amino]cyclohexyl]amino]-4-pyridinyl]-2-thiazolyl]amino]methyl]tetrahydro-
[CAS]

2247481-08-7
[Synonyms]

2H-Pyran-4-carbonitrile, 4-[[[4-[5-chloro-2-[[trans-4-[[(1R)-2-methoxy-1-methylethyl]amino]cyclohexyl]amino]-4-pyridinyl]-2-thiazolyl]amino]methyl]tetrahydro-
[Molecular Formula]

C25H35ClN6O2S
[MOL File]

2247481-08-7.mol
[Molecular Weight]

519.1
Chemical PropertiesBack Directory
[Boiling point ]

694.7±65.0 °C(Predicted)
[density ]

1.28±0.1 g/cm3(Predicted)
[form ]

Solid
[pka]

9.13±0.40(Predicted)
[color ]

White to yellow
Hazard InformationBack Directory
[Uses]

Tambiciclib is a novel, highly selective CDK9 inhibitor critical for regulating transcription elongation. Tambiciclib demonstrated significant in vitro and in vivo efficacy against acute myeloid leukemia (AML)[1].
[IC 50]

CDK9
[References]

[1] Wang L, et al. Discovery of a novel and highly selective CDK9 kinase inhibitor (JSH-009) with potent antitumor efficacy in preclinical acute myeloid leukemia models. Invest New Drugs. 2020 Oct;38(5):1272-1281. DOI:10.1007/s10637-019-00868-3
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