| Identification | Back Directory | [Name]
4-Methoxyfuro[2,3-b]quinolin-8-ol | [CAS]
2255-50-7 | [Synonyms]
Robustine
NPLC 0314
8-Hydroxydictamnine
8-hydroxy dictanmnine
Robustine (Haplophyllum)
4-Methoxyfuro[2,3-b]quinolin-8-ol
Furo[2,3-b]quinolin-8-ol, 4-methoxy- | [Molecular Formula]
C12H9NO3 | [MDL Number]
MFCD01545265 | [MOL File]
2255-50-7.mol | [Molecular Weight]
215.2 |
| Chemical Properties | Back Directory | [Melting point ]
148-149℃ (ethanol ) | [Boiling point ]
411.9±40.0 °C(Predicted) | [density ]
1.378±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [form ]
Solid | [pka]
5.34±0.30(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
Haplophyllum robustum Bge. yields this alkaloid which forms colourless crystals from EtOH. It forms a series of crystalline salts and derivatives including the hydrochloride, m.p. 199-200°C; picrate, m.p. I 79-180°C; acetyl derivative, m.p.174-5°C; methyl derivative, m.p. 140-2°C and the tetrahydrG compound with
m.p.201-2°C. | [Uses]
Robustine, a furoquinoline alkaloid, from Dictamnus albus, exhibits inhibitory potency against human phosphodiesterase 5 (hPDE5A) in vitro[1]. | [Definition]
ChEBI: A quinoline alkaloid that is furo[2,3-b]quinoline substituted by a methoxy and a hydroxy group at positions 4 and 8 respectively. | [IC 50]
PDE5A | [storage]
4°C, protect from light | [References]
Fakhritdinova, Sidyakin, Yunusov,Khim. Prir.Soedin., 1, 107 (1965)
Faizutdinova, Yunusov, ibid, 3, 260 (1967)
Narasimhan, Paradkar, Alurkar, Tetrahedron, 27,1351 (1971) |
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Rhawn Reagent
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