22608-87-3

20357-25-9

22608-87-3

General procedure for the synthesis of 2-amino-4,5-dimethoxybenzaldehyde from 4,5-dimethoxy-2-nitrobenzaldehyde: Pd/C catalyst (5%, 0.5 g) was suspended in a solution of 4,5-dimethoxy-2-nitrobenzaldehyde (3.1 g, 4.74 mmol) in anhydrous THF (10 mL). The reaction mixture was subjected to a hydrogen atmosphere at 50 psi pressure for 15 minutes at room temperature with stirring. Upon completion of the reaction, the mixture was filtered through a diatomaceous earth pad to remove the catalyst. The filtrate was concentrated under reduced pressure and the residue was purified by column chromatography to afford the target product 2-amino-4,5-dimethoxybenzaldehyde (0.85 g, 99% yield).