| Identification | More | [Name]
Methyl 2-amino-4,5-dimethoxybenzoate | [CAS]
26759-46-6 | [Synonyms]
2-AMINO-4,5-DIMETHOXYBENZOIC ACID METHYL ESTER
2-AMINO-4,5-DIMETHOXY METHYL BENZOATE
4,5-DIMETHOXYANTHRANILIC ACID METHYL
4,5-DIMETHOXYANTHRANILIC ACID METHYL ESTER
6-AMINOVERATRIC ACID METHYL ESTER
LABOTEST-BB LT00454153
METHYL 2-AMINO-4,5-DIMETHOXYBENZOATE
METHYL 4,5-DIMETHOXYANTHRANILATE
METHYL 6-AMINO-3,4-DIMETHOXYBENZOATE
METHYL 6-AMINOVERATRATE
TIMTEC-BB SBB008554
2-amino-4,5-dimethoxy-benzate ester
6-AMINO-3,4-DIMETHOXYBENZOIC ACID METHYL ESTER
4,5-DIMETHOXY-2-AMINOBENZOIC ACID METHYL ESTER
3,4-DIMETHOXY-6-AMINOBENZOICACIDMETHYLESTER
Benzoicacid,2-amino-4,5-dimethoxy-methylester
Methyl 4,5-dimethoxyanthranilate, Methyl 6-aminoveratrate | [EINECS(EC#)]
247-967-7 | [Molecular Formula]
C10H13NO4 | [MDL Number]
MFCD00014904 | [Molecular Weight]
211.21 | [MOL File]
26759-46-6.mol |
| Chemical Properties | Back Directory | [Melting point ]
128-133 °C | [Boiling point ]
343.1±37.0 °C(Predicted) | [density ]
1.189±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [form ]
powder to crystal | [pka]
2.68±0.10(Predicted) | [color ]
White to Light yellow to Light orange | [BRN ]
2724754 | [InChI]
InChI=1S/C10H13NO4/c1-13-8-4-6(10(12)15-3)7(11)5-9(8)14-2/h4-5H,11H2,1-3H3 | [InChIKey]
QQFHCCQSCQBKBG-UHFFFAOYSA-N | [SMILES]
C(OC)(=O)C1=CC(OC)=C(OC)C=C1N | [CAS DataBase Reference]
26759-46-6(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S24/25:Avoid contact with skin and eyes .
S22:Do not breathe dust . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
29225090 |
| Hazard Information | Back Directory | [Chemical Properties]
Brown crystalline powder | [Uses]
3-Acetamido-2-hydroxyacetophenone is used in the preparation fo Antitumor Agents in Breast Cancer. | [reaction suitability]
reaction type: solution phase peptide synthesis | [Synthesis]
General procedure for the synthesis of methyl 2-amino-4,5-dimethoxybenzoate from methyl 4,5-dimethoxy-2-nitrobenzoate: 1.9 g (7.2 mmol) of methyl 4,5-dimethoxy-2-nitrobenzoate and 0.2 g of palladium-carbon catalyst were added to a 100 mL round-bottomed flask and dissolved in 50 mL of methanol. Hydrogen was passed into the reaction system and the reaction mixture was stirred at room temperature for 24 hours. The reaction progress was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the brown solid catalyst was removed by filtration. The product was separated and purified by column chromatography (eluent ratio: petroleum ether:ethyl acetate = 10:1, V/V) to afford 1.51 g of the white solid target compound in 88.7% yield with a melting point of 91-93°C. The product was purified by column chromatography (eluent ratio: petroleum ether:ethyl acetate = 10:1, V/V). | [References]
[1] Patent: CN105037279, 2017, B. Location in patent: Paragraph 0047; 0048
[2] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 18, p. 4455 - 4459
[3] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1995, vol. 34, # 10, p. 911 - 913
[4] Justus Liebigs Annalen der Chemie, 1896, vol. 293, p. 190
[5] Journal of the American Chemical Society, 1919, vol. 41, p. 2147 |
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