ChemicalBook--->CAS DataBase List--->2304799-09-3

2304799-09-3

2304799-09-3 Structure

2304799-09-3 Structure
IdentificationBack Directory
[Name]

FLT3-IN-4
[CAS]

2304799-09-3
[Synonyms]

FLT3-IN-4
[Molecular Formula]

C23H25N7O2
[MDL Number]

MFCD32067953
[MOL File]

2304799-09-3.mol
[Molecular Weight]

431.49
Chemical PropertiesBack Directory
[Boiling point ]

589.1±50.0 °C(Predicted)
[density ]

1.32±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[form ]

Solid
[pka]

12.68±0.70(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Description]

FLT3-IN-4 is a potent and orally effective Fms-like tyrosine receptor kinase 3 (FLT3; IC50=7 nM) inhibitor for treating acute myelogenous leukemia[1].

FLT3-IN-4 (Compound 9u) shows potent inhibitory activities against MV4-11 and Molm-13 cells with IC50 values are 0.089±0.001 nM and 0.022±0.003 nM, respectively[1].

[References]

[1]. Yuan X, et al. Identification of Pyrrolo[2,3- d]pyrimidine-Based Derivatives as Potent and Orally Effective Fms-like Tyrosine Receptor Kinase 3 (FLT3) Inhibitors for Treating Acute Myelogenous Leukemia. J Med Chem. 2019 Apr 25;62(8):4158-4173.

Spectrum DetailBack Directory
[Spectrum Detail]

FLT3-IN-4(2304799-09-3)1HNMR
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