| Identification | More | [Name]
L-AP4 | [CAS]
23052-81-5 | [Synonyms]
GDF5
CDMP1
L-AP4
L-APB
SYNS2
GDF-5 mouse
GDF-5 human
BMP-14/ CDMP-1
BMP-14 (GDF-5/CDMP-1) human
2-ammonio-4-phosphonatobutanoate
(S)-4-Phosphono-2-aminobutyric acid
(2S)-2-Amino-4-phosphonobutyric acid
(S)-4-Phosphono-2-aminobutanoic acid
(S)-2-aMino-4-phosphonobutanoic acid
L(+)-2-AMINO-4-PHOSPHONOBUTANOIC ACID
L-(+)-2-AMINO-4-PHOSPHONOBUTYRIC ACID
(2S)-2-amino-4-phosphonobutanoic acid
L(+)-2-AMINO-4-PHOSPHONOBUTYRIC ACID 97%
L(+)-2-Amino-4-phosphonobutyric acid,97%
Butanoic acid, 2-amino-4-phosphono-, (2S)-
L(+)-2-Amino-4-phosphonobutanoic acid (L-AP4)
L-(+)-2-AMINO-4-PHOSPHONOBUTYRIC ACID (L-AP4)
Anti-GDF5 (C-terminal) antibody produced in rabbit
L-(+)-2-Amino-4-phosphonobutyric Acid - CAS 23052-81-5 - Calbiochem | [EINECS(EC#)]
200-258-5 | [Molecular Formula]
C4H10NO5P | [MDL Number]
MFCD00083244 | [Molecular Weight]
183.1 | [MOL File]
23052-81-5.mol |
| Chemical Properties | Back Directory | [Appearance]
white to off-white crystalline powder | [Melting point ]
207-215 °C | [Boiling point ]
491.7±55.0 °C(Predicted) | [density ]
1.628±0.06 g/cm3(Predicted) | [storage temp. ]
0-6°C | [solubility ]
H2O : 50 mg/mL (273.07 mM; Need ultrasonic) | [form ]
solid | [pka]
2.19±0.10(Predicted) | [color ]
White | [Water Solubility ]
Soluble to 5 mM in water and to 100 mM in 1eq. NaOH | [Sensitive ]
Light Sensitive | [CAS DataBase Reference]
23052-81-5(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [RTECS ]
ES7191700 |
| Hazard Information | Back Directory | [Description]
Metabotropic glutamate receptors (mGluR) function to modulate excitatory synaptic transmission in the brain. Eight subtypes (1-8) and multiple splice variants of the mGluR have been identified and grouped based on their pharmacological properties. Group I mGluRs (subtypes 1 and 5) activate the phosphatidyl inositol pathway, while Group II (2 and 3) and Group III (4, 6, 7, and 8) inhibit adenylyl cyclase. L-AP4, an analog of L-glutamic acid, is a selective Group III mGluR agonist that functions presynaptically to suppress glutamate release (IC50 = 2.5 μM).1,2,3 L-AP4 has been shown to depress synaptic transmission in glutamatergic pathways in the hippocampus, olfactory bulb, and retina as well as act as an agonist at the quisqualate-sensitized AP6 site in hippocampus.1 | [Chemical Properties]
white to off-white crystalline powder | [Uses]
L(+)-2-Amino-4-phosphonobutanoic acid (L-AP4) is a mGluR-4/6 receptor agonist. | [Uses]
Metabotropic glutamate receptors (mGluR) function to modulate excitatory synaptic transmission in the brain. Eight subtypes (1-8) and multiple splice variants of the mGluR have been identified and grouped based on their pharmacological properties. Group I mGluRs (subtypes 1 and 5) activate the phosphatidyl inositol pathway, while Group II (2 and 3) and Group III (4, 6, 7, and 8) inhibit adenylyl cyclase. L-AP4, an analog of L-glutamic acid, is a selective Group III mGluR agonist that functions presynaptically to suppress glutamate release (IC50 = 2.5 μM). L-AP4 has been shown to depress synaptic transmission in glutamatergic pathways in the hippocampus, olfactory bulb, and retina as well as act as an agonist at the quisqualate-sensitized AP6 site in hippocampus. | [Definition]
ChEBI: (2S)-2-amino-4-phosphonobutanoic acid is a non-proteinogenc L-alpha-amino acid that is L-alpha-aminobutyric acid in which one of the hydrogens of the terminal methyl group has been replaced by a dihydroxy(oxido)-lambda(5)-phosphanyl group. It is a potent and selective agonist for the group III metabotropic glutamate receptors (mGluR4/6/7/8). It has a role as a metabotropic glutamate receptor agonist. It is a non-proteinogenic L-alpha-amino acid and a member of phosphonic acids. | [Biological Activity]
Selective group III metabotropic glutamate receptor agonist. Synaptic depressant. Agonist at the quisqualate-sensitized AP6 site in hippocampus. Also available as part of the Group III mGlu Receptor Tocriset™ and Mixed mGlu Receptor Tocriset™ . | [storage]
Store at -20°C |
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