| Chemical Properties | Back Directory | [Boiling point ]
1116.1±65.0 °C(Predicted) | [density ]
1.34±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
powder | [pka]
13.79±0.20(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Uses]
cis-VZ185 is a VHL-based PROTACs degrader with the activity of degrading BRD9 and BRD7. cis-VZ185 can be optimized from suboptimal compounds by optimizing the connection mode and linker, and has efficient, rapid and selective degradation of BRD9 and its homologous protein BRD7. | [Biological Activity]
cisVZ185 is the inactive cis-isomer of and the recommended negative control for the potent and selective dual BRD7 and BRD9 degrader VZ185. | [storage]
Store at -20°C | [References]
[1] Iterative design and optimization of initially inactive proteolysis targeting chimeras (PROTACs) identify VZ185 as a potent, fast, and selective von Hippel–Lindau (VHL)?… |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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