| Identification | Back Directory | [Name]
3-Isoxazolecarboxamide, N-[1-[[2,4-bis(trifluoromethyl)phenyl]methyl]-1H-pyrazol-4-yl]-5-(2-furanyl)- | [CAS]
2323027-38-7 | [Synonyms]
Ceapin-A7
3-Isoxazolecarboxamide, N-[1-[[2,4-bis(trifluoromethyl)phenyl]methyl]-1H-pyrazol-4-yl]-5-(2-furanyl)- | [Molecular Formula]
C20H12F6N4O3 | [MDL Number]
MFCD31567506 | [MOL File]
2323027-38-7.mol | [Molecular Weight]
470.32 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
Soluble in DMSO (>25 mg/ml) | [form ]
solid | [color ]
White | [Stability:]
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. | [InChI]
InChI=1S/C20H12F6N4O3/c21-19(22,23)12-4-3-11(14(6-12)20(24,25)26)9-30-10-13(8-27-30)28-18(31)15-7-17(33-29-15)16-2-1-5-32-16/h1-8,10H,9H2,(H,28,31) | [InChIKey]
UJTDYOXTXGBHEG-UHFFFAOYSA-N | [SMILES]
O1C(C2=CC=CO2)=CC(C(NC2=CN(CC3=CC=C(C(F)(F)F)C=C3C(F)(F)F)N=C2)=O)=N1 |
| Hazard Information | Back Directory | [Description]
Ceapin-A7 (2323027-38-7) is a selective inhibitor (IC50 = 590 nM) of transcription factor ATF6α, one of the three branches of the unfolded protein response.1 It inhibits activation of ATF6α in response to ER stress without inhibiting ER-bound transcription factors ATF6? or SREBP or the IRE1 or PERK branches of the UPR.? Ceapin-A7 also show no toxicity to unstressed cells. It induces neomorphic association of the ER and peroxisomes by directly tethering the cytosolic domain of ATF6a to the peroxisomal transporter ABCD3 without inhibiting its transporter activity.2 See companion activator 10-3973. | [Uses]
Ceapin-A7 is a selective blocker of ATF6α signaling in response to ER stress, with an IC50 of 0.59 μM. Ceapin-A7 can be used to explore both the mechanism of activation of ATF6α and its role in pathological settings[1]. | [storage]
Store at -20°C | [References]
Gallagher et al. (2016), Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch; eLife 5 e11878
Torres et al. (2019), Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether; eLife 8 e46595 |
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| Company Name: |
ChemShuttle, Inc.
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| Telephone: |
0510-83588313-811 18800520310 |
| Website: |
www.jiehuapharma.com/ |
| Company Name: |
Bide Pharmatech Ltd.
|
| Telephone: |
400-1647117 13681763483 |
| Website: |
https://www.bidepharm.com/ |
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