| Chemical Properties | Back Directory | [Boiling point ]
350.0±42.0 °C(predicted) | [density ]
1.548±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
12.98±0.70(predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
A3373, a novel chemical inhibitor of Phospholipase D1 (PLD1) and PLD2, with IC50 of 325 nM and 15.15?μM, respectively, inhibits LPS-induced immune response and plays important roles in autoimmune arthritis, bone demineralization and osteoclastogenesis[1][2]. | [IC 50]
PLD1: 325 nM (IC50); PLD2: 15.15 μM (IC50) | [References]
[1] Won Chan Hwang, et al. Inhibition of phospholipase D1 induces immunogenic cell death and potentiates cancer immunotherapy in colorectal cancer.Exp Mol Med. 2022 Sep;54(9):1563-1576. DOI:10.1038/s12276-022-00853-6
[2] Jin-Sil Park, et al. A newly developed PLD1 inhibitor ameliorates rheumatoid arthritis by regulating pathogenic T and B cells and inhibiting osteoclast differentiation. Immunol Lett. 2023 Sep 16:263:87-96. DOI:10.1016/j.imlet.2023.09.007 |
|
|