| Identification | Back Directory | [Name]
7H-Pyrrolo[2,3-d]pyrimidine-6-carboxamide, 7-cyclopentyl-2-[[5-[4-[4-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]butyl]-1-piperazinyl]-2-pyridinyl]amino]-N,N-dimethyl- | [CAS]
2349356-39-2 | [Synonyms]
7H-Pyrrolo[2,3-d]pyrimidine-6-carboxamide, 7-cyclopentyl-2-[[5-[4-[4-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]butyl]-1-piperazinyl]-2-pyridinyl]amino]-N,N-dimethyl- | [Molecular Formula]
C42H49N11O7 | [MOL File]
2349356-39-2.mol | [Molecular Weight]
819.91 |
| Chemical Properties | Back Directory | [density ]
1.49±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
10.68±0.40(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Uses]
BSJ-04-132 is a PROTAC connected by ligands for Cereblon and CDK. BSJ-04-132 is a potent and selective Ribociclib-based CDK4 degrader (PROTAC), with IC50s of 50.6 nM and 30 nM for CDK4/D1 and CDK6/D1, respectively. BSJ-04-132 does not induce CDK6 and IKZF1/3 degradation. BSJ-04-132 has anti-cancer activity[1]. | [IC 50]
CDK4/D1: 50.6 nM (IC50); CDK6/D1: 30 nM (IC50) | [storage]
Store at -20°C | [References]
[1] Baishan Jiang, et al. Development of Dual and Selective Degraders of Cyclin-Dependent Kinases 4 and 6. Angew Chem Int Ed Engl. 2019 May 6;58(19):6321-6326. DOI:10.1002/anie.201901336 |
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