| Identification | Back Directory | [Name]
8-GINGEROL | [CAS]
23513-08-8 | [Synonyms]
GINGEROL [8]
8-Gingerol ,98%
(s)-(+)-3-dodecanon
8-GINGEROL USP/EP/BP
[8]-Gingerol Standard
8]-Gingerol >=95% (HPLC)
8-Gingerol, 98%, from Zingiber officinale Roscoe
5-HYDROXY-1-(4-HYDROXY-3-METHOXYPHENYL)-3-DODECANONE
(S)-10-Oxo-12-(3-methoxy-4-hydroxyphenyl)dodecane-8-ol
(5S)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-dodecanone
(5S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)dodecan-3-one
(5S)-1-(3-Methoxy-4-hydroxyphenyl)-5-hydroxydodecane-3-one
(s)-(+)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-dodecanone
3-Dodecanone, 5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-, (5S)- | [Molecular Formula]
C19H30O4 | [MDL Number]
MFCD00877794 | [MOL File]
23513-08-8.mol | [Molecular Weight]
322.44 |
| Chemical Properties | Back Directory | [Boiling point ]
476.4±35.0 °C(Predicted) | [density ]
1.058±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [solubility ]
methanol: soluble1mg/mL, clear, colorless | [form ]
powder | [pka]
10.02±0.20(Predicted) | [color ]
white to light yellow | [Water Solubility ]
practically insoluble in water | [BRN ]
2059802 | [InChI]
InChI=1S/C19H30O4/c1-3-4-5-6-7-8-16(20)14-17(21)11-9-15-10-12-18(22)19(13-15)23-2/h10,12-13,16,20,22H,3-9,11,14H2,1-2H3/t16-/m0/s1 | [InChIKey]
BCIWKKMTBRYQJU-INIZCTEOSA-N | [SMILES]
C(C1=CC=C(O)C(OC)=C1)CC(=O)C[C@@H](O)CCCCCCC | [LogP]
3.881 (est) |
| Hazard Information | Back Directory | [Chemical Properties]
A white waxy solid, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from dried ginger and fresh ginger. | [Uses]
8-Gingerol has been observed to exhibit anti-oxidant behaviour towards lipids and is effective in suppressing obesity and adipose tissue inflammation. | [Definition]
ChEBI:(8)-Gingerol is a beta-hydroxy ketone, a member of phenols and a monomethoxybenzene. | [Biological Activity]
[8]-Gingerol is a bioactive compound found in ginger (Zingiber officinale) with anti-inflammatory and antioxidant activity. | [in vivo]
8-Gingerol (50, 100 mg/kg, i.p., once daily for 7 days) can suppress the humoral and cellular immune responses in mice, likely by directly inhibiting activated T cells and B cells[4].
8-Gingerol (10, 20 mg/kg, i.p., once daily for 14 days) improves ISO-induced myocardial fibrosis in mice by regulating the PI3K/Akt/mTOR signaling pathway, inhibiting oxidative stress, apoptosis, and autophagy[5]. | Animal Model: | OVA-immunized mice (BALB/c male mice, 5 weeks old, 18-22g, immunized with ovalbumin (OVA))[4] | | Dosage: | 25, 50, 100 mg/kg | | Administration: | Intraperitoneal injection (i.p.), once daily for 7 consecutive days | | Result: | Significantly suppressed LPS-, ConA-, and OVA-induced splenocyte proliferation in OVA-immunized mice and significantly reduced the percentage of CD19+ B cells and CD3+ T cells at high doses (50, 100 mg/kg) |
| Animal Model: | Isoproterenol (ISO)-induced myocardial fibrosis (MF) mouse model, Kunming mice (male, 6-8 weeks old, 15-20g)[5] | | Dosage: | 10 mg/kg (low dose), 20 mg/kg (high dose) | | Administration: | Intraperitoneal injection (i.p.), once daily for 14 days | | Result: | Significantly reduced the heart weight, left ventricle weight index, CK, LDH levels, ROS generation, and pathological heart damage induced by ISO. |
| [IC 50]
MMP-9; Caspase-9 | [storage]
Store at -20°C, sealed storage, away from moisture and light |
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