| Identification | Back Directory | [Name]
Curcumol | [CAS]
4871-97-0 | [Synonyms]
CURCUMOL
5,8-Epoxy-10(14)-guaien-8-ol
(3S,3aS,5S,6R,8aS)-Octahydro-3-methyl-8-methylene-5-(1-methylethyl)-6H-3a,6-epoxyazulen-6-ol
6H-3a,6-Epoxyazulen-6-ol, octahydro-3-methyl-8-methylene-5-(1-methylethyl)-, (3S,3aS,5S,6R,8aS)-
(3s-(3a,3aa,5a,6a,8ab))-octahydro-3-methyl-8-methylene-5-(1-methylethyl)-6h-3a,6-epoxyazulen-6-ol
(3S-(3alpha,3Aalpha,5alpha,6alpha,8abeta))-octahydro-3-methyl-8-methylene-5-(1-methylethyl)-6H-3A,6-epoxyazulen-6-ol | [Molecular Formula]
C15H24O2 | [MDL Number]
MFCD00272163 | [MOL File]
4871-97-0.mol | [Molecular Weight]
236.35 |
| Chemical Properties | Back Directory | [Melting point ]
141.0 to 145.0 °C | [Boiling point ]
334.5±42.0 °C(Predicted) | [density ]
1.06±0.1 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [solubility ]
DMSO:55.67(Max Conc. mg/mL);235.54(Max Conc. mM)
DMF:20.0(Max Conc. mg/mL);84.62(Max Conc. mM)
Ethanol:28.5(Max Conc. mg/mL);120.58(Max Conc. mM) | [form ]
neat | [pka]
13.02±0.60(Predicted) | [color ]
White to Light yellow | [InChIKey]
QRMPRVXWPCLVNI-YYFQZIEXSA-N | [LogP]
3.276 (est) | [CAS DataBase Reference]
4871-97-0 |
| Hazard Information | Back Directory | [Definition]
ChEBI: Curcumol is a sesquiterpenoid. | [Biological Activity]
Curcumol is a biologically active sesquiterpene with many pharmacological activities such as anticancer, antimicrobial, antifungal, antiviral and anti-inflammatory. It efficiently induces apoptosis in many cancer cells by targeting key signaling pathways such as MAPK/ERK, PI3K/Akt and NF-κB, which are often dysregulated in several cancers. | [in vitro]
Curcumol ((-)-Curcumol) is the major component extracted from root of Rhizoma Curcumae . Curcumol exerts anticancer effect in cholangiocarcinoma cells via down-regulating CDKL3. It induces cell cycle arrest in colon cancer cells via reactive oxygen species and Akt/ GSK3β/cyclin D1 pathway. It suppresses breast cancer cell metastasis by inhibiting MMP-9 via JNK1/2 and Akt-dependent NF-κB signaling pathways. | [storage]
Store at 4°C |
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