| Identification | Back Directory | [Name]
1H-Isoindole-1,3(2H)-dione, 5-(3-aminopropyl)-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1) | [CAS]
2357110-84-8 | [Synonyms]
Thalidomide-4-C3-NH2, HCl salt
Thalidomide-4-C3-NH2 hydrochloride
Thalidomide-4-C3-NH2 hydrochloride?, Thalidomide-4-C3-NH2 HCl
1H-Isoindole-1,3(2H)-dione, 5-(3-aminopropyl)-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1) | [Molecular Formula]
C16H18ClN3O4 | [MOL File]
2357110-84-8.mol | [Molecular Weight]
351.79 |
| Hazard Information | Back Directory | [Uses]
Thalidomide-4-C3-NH2 hydrochloride is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-4-C3-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs[1]. | [IC 50]
Cereblon | [References]
[1] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-994. DOI:10.1016/j.stem.2020.07.019 |
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