| Identification | Back Directory | [Name]
5,6-dichloro-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione | [CAS]
2648939-40-4 | [Synonyms]
Thalidomide-5,6-Cl
1H-Isoindole-1,3(2H)-dione, 5,6-dichloro-2-(2,6-dioxo-3-piperidinyl)-
5,6-dichloro-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione | [Molecular Formula]
C13H8Cl2N2O4 | [MDL Number]
MFCD34167838 | [MOL File]
2648939-40-4.mol | [Molecular Weight]
327.12 |
| Hazard Information | Back Directory | [Uses]
Thalidomide-5,6-Cl is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5,6-Cl can be connected to the ligand for protein by a linker to form PROTACs. | [IC 50]
Cereblon | [References]
[1] Zhang NN, et, al. A Thermostable mRNA Vaccine against COVID-19. Cell. 2020 Sep 3;182(5):1271-1283.e16. DOI:10.1016/j.cell.2020.07.024 |
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