| Identification | Back Directory | [Name]
4-Quinolinamine, 7-iodo-N-(3,4,5-trimethoxyphenyl)- | [CAS]
2361545-75-5 | [Synonyms]
PKN3 inhibitor compound 16
4-Quinolinamine, 7-iodo-N-(3,4,5-trimethoxyphenyl)- | [Molecular Formula]
C18H17IN2O3 | [MOL File]
2361545-75-5.mol | [Molecular Weight]
436.24 |
| Chemical Properties | Back Directory | [Boiling point ]
502.5±50.0 °C(Predicted) | [density ]
1.575±0.06 g/cm3(Predicted) | [solubility ]
Acetonitrile: Slightly soluble: 0.1-1 mg/ml
DMSO: Sparingly soluble: 1-10 mg/ml | [pka]
5.71±0.50(Predicted) |
| Hazard Information | Back Directory | [Uses]
PKN3-IN-1 (compound 16) inhibits PKN3 (serine/threonine protein kinase 3) and GAK (cyclin G-associated kinase) with IC50 of 0.014 μM and Ki of 0.0044 μM respectively. PKN3-IN-1 is a potential tool compound to study the cell biology of PKN3 and its role in pancreatic and prostate cancer and T-cell acute lymphoblastic leukemia [1]. | [References]
[1] Asquith CRM, et al. Identification of 4-Anilinoquin(az)oline as a Cell-Active Protein Kinase Novel 3 (PKN3) Inhibitor Chemotype. ChemMedChem. 2022 Jun 20;17(12):e202200161. DOI:10.1002/cmdc.202200161
[2] Asquith CRM, et al. Identification and Optimization of 4-Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase. ChemMedChem. 2018 Jan 8;13(1):48-66. |
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