| Identification | Back Directory | [Name]
2,6-dimethoxy-4-[5-phenyl-4-(thiophen-2-yl)-1H-im
idazol-2-yl]phenol hydrochloride | [CAS]
2361799-64-4 | [Synonyms]
DPTIP hydrochloride
2,6-dimethoxy-4-[5-phenyl-4-(thiophen-2-yl)-1H-im
idazol-2-yl]phenol hydrochloride | [Molecular Formula]
C21H19ClN2O3S | [MOL File]
2361799-64-4.mol | [Molecular Weight]
414.9 |
| Hazard Information | Back Directory | [Uses]
DPTIP hydrochloride is a potent brain penetrant neutral sphingomyelinase 2 (N-SMase 2) inhibitor (exosome inhibitor), with an IC50 of 30 nM[1][2]. | [IC 50]
N-SMase 2: 30 nM (IC50) | [References]
[1] Camilo Rojas, et al. DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation. Sci Rep. 2018 Dec 7;8(1):17715. DOI:10.1038/s41598-018-36144-2
[2] Huarui Zhang, et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1322-1330. DOI:10.1080/14756366.2020.1754814 |
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