| Identification | Back Directory | [Name]
MMP-8 INHIBITOR I | [CAS]
236403-25-1 | [Synonyms]
MMP 8-I
MMP-8 INHIBITOR I
(3R)-(+)-[2-(4-METHOXYBENZENESULFONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-HYDROXAMATE]
3-Isoquinolinecarboxamide, 1,2,3,4-tetrahydro-N-hydroxy-2-[(4-methoxyphenyl)sulfonyl]-, (3R)- | [Molecular Formula]
C17H18N2O5S | [MDL Number]
MFCD02683950 | [MOL File]
236403-25-1.mol | [Molecular Weight]
362.4 |
| Hazard Information | Back Directory | [Description]
MMP-8 Inhibitor I is a selective inhibitor of the neutrophil collagenase matrix metalloproteinase-8 (MMP-8) with an IC50 value of 4 nM.1 This inhibitor does not target the activities of other MMPs in vitro.2,3 MMP-8 cleaves interstitial collagens and has exhibited activity in atherosclerotic plaques, angiogenesis, and stem cell mobilization.4 Additionally, MMP-8 expression is observed in normal mammary epithelial cells, whereas a loss of expression is observed in human ductal carcinoma in situ and the deletion of MMP-8 accelerates tumor onset in a mouse model of aggressive breast cancer.5,6 | [Uses]
MMP 8-I is a matrix metalloproteinase 8 inhibitor. Matrix metalloproteinases are involved with tight junction protein degradation in endothelial cells. | [in vivo]
MMP-8 inhibitor-1 (compound 21) (100 mg/kg, orally) has not significant oral bioavailability, with maximal plasma levels (Cmax) of only 2.3 mg/mL[1]. | [IC 50]
MMP-8 |
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| Company Name: |
Alabiotech Inc.
|
| Tel: |
001-619-354-5251 |
| Website: |
www.alabiotech-e.com |
|