| Identification | Back Directory | [Name]
(3E,5E)-3,5-Bis[[3-(trifluoromethyl)phenyl]methylene]-4-piperidinone | [CAS]
2369030-41-9 | [Synonyms]
ROS-generating agent 1
3,5-Bis((E)-3-(trifluoromethyl)benzylidene)piperidin-4-one
(3E,5E)-3,5-Bis[[3-(trifluoromethyl)phenyl]methylene]-4-piperidinone | [Molecular Formula]
C21H15F6NO | [MOL File]
2369030-41-9.mol | [Molecular Weight]
411.34 |
| Chemical Properties | Back Directory | [Boiling point ]
506.3±50.0 °C(Predicted) | [density ]
1.363±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [form ]
Solid | [pka]
5.42±0.20(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
ROS-generating agent 1 (Compound 2c) covalently modifies the Sec-498 residue of TrxR to generate ROS. ROS-generating agent 1 reduces intracellular TrxR protein level. ROS-generating agent 1 results in ROS-dependent apoptosis and ferroptosis of NCI-H460 cells. ROS-generating agent 1 has anti-cancer activities[1]. | [References]
[1] Liu X, et al. Tumor killing by a dietary curcumin mono-carbonyl analog that works as a selective ROS generator via TrxR inhibition. Eur J Med Chem. 2023 Mar 15;250:115191. DOI:10.1016/j.ejmech.2023.115191 |
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