| Identification | Back Directory | [Name]
nardosinone | [CAS]
23720-80-1 | [Synonyms]
nardosinone
Nardosinone, 98%, from Nardostachys jatamansi DC.
1,1,9β,9aβ-Tetramethyl-3aβ,7,8,9,9a,9bβ-hexahydro-1H-naphtho[2,1-c][1,2]dioxole-5(4H)-one
(3aR)-1,3aβ,4,7,8,9,9a,9bβ-Octahydro-1,1,9β,9aβ-tetramethyl-5H-naphtho[2,1-c][1,2]dioxol-5-one
(3aR,9R,9aR,9bS)-1,3a,4,7,8,9,9a,9b-Octahydro-1,1,9,9a-tetramethyl-5H-naphtho[2,1-c][1,2]dioxol-5-one
5H-Naphtho[2,1-c][1,2]dioxol-5-one,1,3a,4,7,8,9,9a,9b-octahydro-1,1,9,9a-tetramethyl-, (3aR,9R,9aR,9bS)- | [Molecular Formula]
C15H22O3 | [MDL Number]
MFCD21363103 | [MOL File]
23720-80-1.mol | [Molecular Weight]
250.33 |
| Chemical Properties | Back Directory | [Melting point ]
108-110℃ | [Boiling point ]
330.2±32.0 °C(Predicted) | [density ]
1.11 | [storage temp. ]
-20°C | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
White to Off-White | [InChI]
InChI=1S/C15H22O3/c1-9-6-5-7-10-11(16)8-12-13(15(9,10)4)14(2,3)18-17-12/h7,9,12-13H,5-6,8H2,1-4H3/t9-,12-,13+,15+/m1/s1 | [InChIKey]
KXGHHSIMRWPVQM-JWFUOXDNSA-N | [SMILES]
O1C(C)(C)[C@@]2([H])[C@]3(C)C(=CCC[C@H]3C)C(=O)C[C@@]2([H])O1 |
| Hazard Information | Back Directory | [Chemical Properties]
White crystalline powder, easily soluble in methanol, almost insoluble in ether, derived from the dried roots and rhizomes of Nardostachys chinensis Batal. | [Uses]
Nardosinone reduces neuronal injury and protects H9c2 cardiac cells from angiotensin II-induced hypertrophy which may give rise to heart failure. Enhancer of nerve growth factor (NGF). | [Biological Activity]
Nardosinone is a main active ingredient from medical plant Nardostachys jatamansi. Nardosinone exhibits varies pharmacological effects including anti-inflammatory and anti-hypertrophic in cardiomyocytes. Nardosinone enhances activity of the nerve growth factor and promotes neural stem cells proliferation and differentiation. The molecular mechanism of its activity remains unclear. |
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