| Identification | Back Directory | [Name]
1,7-Dihydroxy-2,3,8-trimethoxy-6-methylanthracene-9,10-dione | [CAS]
70588-05-5 | [Synonyms]
Obtusin
1,7-Dihydroxy-2,3,8-trimethoxy-6-methyl-9,10-anthraquinone
1,7-Dihydroxy-2,3,8-trimethoxy-6-methylanthracene-9,10-dione
9,10-Anthracenedione, 1,7-dihydroxy-2,3,8-trimethoxy-6-methyl-
1,7-Dihydroxy-2,3,8-trimethoxy-6-methylanthracene-9,10-dioneObtusin
Obtusin,1,7-Dihydroxy-2,3,8-trimethoxy-6-methylanthracene-9,10-dione | [Molecular Formula]
C18H16O7 | [MDL Number]
MFCD13195592 | [MOL File]
70588-05-5.mol | [Molecular Weight]
344.32 |
| Chemical Properties | Back Directory | [Melting point ]
244.5-246.0 °C | [Boiling point ]
614.9±55.0 °C(Predicted) | [density ]
1.409±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
6.16±0.20(Predicted) | [color ]
Yellow to orange |
| Hazard Information | Back Directory | [Uses]
Obtusin, isolated from Cassia obtusifolia Linn seed, is a highly selective and competitive human monoamine oxidase-A (hMAO-A) inhibitor with an IC50 of 11.12 μM and a Ki of 6.15 μM. Obtusin plays a preventive role in neurodegenerative diseases, especially anxiety and depression[1]. | [Definition]
ChEBI: Obtusin is a dihydroxyanthraquinone. | [storage]
Store at -20°C | [References]
[1] Paudel P, et al. In Vitro and in Silico Human Monoamine Oxidase Inhibitory Potential of Anthraquinones, Naphthopyrones, and Naphthalenic Lactones from Cassia obtusifolia Linn Seeds. ACS Omega. 2019 Sep 18;4(14):16139-16152. DOI:10.1021/acsomega.9b02328 |
|
|