ChemicalBook--->CAS DataBase List--->2374856-75-2

2374856-75-2

Request For Quotation
2374856-75-2 Structure

2374856-75-2 Structure
IdentificationBack Directory
[Name]

(5S,5'S)-5,5'-((((5,5'-(2,2'-dichloro-[1,1'-biphenyl]-3,3'-diyl)bis(3-methoxypyrazine-5,2-diyl))bis(methylene))bis(azanediyl))bis(methylene))bis(pyrrolidin-2-one)
[CAS]

2374856-75-2
[Synonyms]

Evixapodlin
PD-1/PD-L1-IN 7
(5S,5'S)-5,5'-((((5,5'-(2,2'-DICHLORO-[1,1'-BIPHENYL]-3,3'-DIYL)BIS(3-METHOXYPYRAZINE-5,2-DIYL))BIS(
2-Pyrrolidinone, 5,5'-[(2,2'-dichloro[1,1'-biphenyl]-3,3'-diyl)bis[(3-methoxy-5,2-pyrazinediyl)methyleneiminomethylene]]bis-, (5S,5'S)-
(5S,5'S)-5,5'-((((5,5'-(2,2'-dichloro-[1,1'-biphenyl]-3,3'-diyl)bis(3-methoxypyrazine-5,2-diyl))bis(methylene))bis(azanediyl))bis(methylene))bis(pyrrolidin-2-one)
[Molecular Formula]

C34H36Cl2N8O4
[MOL File]

2374856-75-2.mol
[Molecular Weight]

691.61
Chemical PropertiesBack Directory
[Boiling point ]

817.1±65.0 °C(Predicted)
[density ]

1.310±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : 50 mg/mL (72.30 mM; Need ultrasonic)
[form ]

Solid
[pka]

15.81±0.40(Predicted)
[color ]

White to yellow
Hazard InformationBack Directory
[Uses]

Evixapodlin (GS-4224) is a human PD-1/PD-L1 protein/protein interaction inhibitor with an IC50 of 0.213 nM. Evixapodlin has anticancer and antiviral functions[1].
[in vivo]

Evixapodlin (Compound 139; 10-50 mg/kg; intraperitoneal injection, daily, for 6 days) treatment shows >90% PD-L1 target occupancy (TO) on the tumor cells. Evixapodlin significantly inhibits tumor growth in a human PD-L1 expressing MC38 mouse colorectal tumor model[1].

Animal Model:Female C57BL/6 mice injected with MC38 tumor cells[1]
Dosage:10 mg/kg, 25 mg/kg, and 50 mg/kg
Administration:Intraperitoneal injection, daily, for 6 days
Result:Showed greater than 90% TO on the tumors and inhibited tumor growth in vivo.
[References]

[1] Evangelos Aktoudianakis, et al. Pd-1/pd-l1 inhibitors. WO2019160882A1.
Spectrum DetailBack Directory
[Spectrum Detail]

(5S,5'S)-5,5'-((((5,5'-(2,2'-dichloro-[1,1'-biphenyl]-3,3'-diyl)bis(3-methoxypyrazine-5,2-diyl))bis(methylene))bis(azanediyl))bis(methylene))bis(pyrrolidin-2-one)(2374856-75-2)1HNMR
2374856-75-2 suppliers list
Company Name: ShangHai Caerulum Pharma Discovery Co., Ltd.  
Telephone: 18149758185 18149758185
Website: www.caerulumpharma.com
Company Name: Shanghai Beckham Medical Technology Co., Ltd  
Telephone: 13816613772
Website: https://www.chemicalbook.com/ShowSupplierProductsList16976/0_EN.htm
Company Name: Shanghai EFE Biological Technology Co., Ltd.  
Telephone: 021-65675885 18964387627
Website: http://www.efebio.com
Company Name: Shanghai SuperLan Chemcial Technique Centre  
Telephone: 0-2022843681 15618226720
Website: www.chemicalbook.com/showsupplierproductslist19886/0_en.htm
Company Name: Shandong utilizing biological technology co., LTD  
Telephone: 18669728830 15966937598
Website:
Company Name: ANHUI WITOP BIOTECH CO., LTD  
Telephone: +8618071025641
Website: www.chemicalbook.com/ShowSupplierProductsList418627/0_EN.htm
Company Name: Chunchuang (Wuhan) Technology Co., Ltd  
Telephone: 15727060112
Website: www.chemicalbook.com/showsupplierproductslist1427518/0_en.htm
Company Name: Jinan Jiuli Biotechnology Co. , Ltd.  
Telephone: 15865264761
Website: www.chemicalbook.com/ShowSupplierProductsList89365/0_EN.htm
Company Name: Beijing Jin Ming Biotechnology Co., Ltd.  
Telephone: 010-60605840
Website: http://www.jm-bio.com/
Company Name: Bide Pharmatech Ltd.  
Telephone: 400-1647117 13681763483
Website: https://www.bidepharm.com/
Company Name: InvivoChem  
Telephone: 13549236410
Website: https://www.invivochem.cn/
Company Name: TargetMol Chemicals Inc.  
Telephone: 4008200310 15002144251
Website: https://www.targetmol.cn/
Company Name: Jinan Demai Medical Technology Co., LTD  
Telephone: 18669728830 15806766175
Website: https://www.demaichem.com/
Company Name: Shanghai Tachizaki Biomedical Research Center  
Telephone: 18014399201
Website: http://www.chemlab-tachizaki.com/
Company Name: Nantong QuanYi Biotechnology Co., Ltd  
Telephone: 0513-66337626 18051384581
Website: https://www.chemhifuture.com/
Company Name: Beijing Boorsen Biotechnology Co., Ltd  
Telephone: 400-901-9800 18611424007
Website: www.bioss.com.cn/
Company Name: Wuhan Acumen Bio-Technology Co.,ltd  
Telephone: 027-027-16602739303 16602739303
Website: www.yjybiochem.com/
Company Name: Anqing YanZhi Pharma Discovery Co.,Ltd.  
Telephone: 18055651951
Website:
Tags:2374856-75-2 Related Product Information
2374856-75-2 25316-40-9 142217-69-4 98-92-0 1374853-91-4