| Identification | Back Directory | [Name]
(5S,5'S)-5,5'-((((5,5'-(2,2'-dichloro-[1,1'-biphenyl]-3,3'-diyl)bis(3-methoxypyrazine-5,2-diyl))bis(methylene))bis(azanediyl))bis(methylene))bis(pyrrolidin-2-one) | [CAS]
2374856-75-2 | [Synonyms]
Evixapodlin
PD-1/PD-L1-IN 7
(5S,5'S)-5,5'-((((5,5'-(2,2'-DICHLORO-[1,1'-BIPHENYL]-3,3'-DIYL)BIS(3-METHOXYPYRAZINE-5,2-DIYL))BIS(
2-Pyrrolidinone, 5,5'-[(2,2'-dichloro[1,1'-biphenyl]-3,3'-diyl)bis[(3-methoxy-5,2-pyrazinediyl)methyleneiminomethylene]]bis-, (5S,5'S)-
(5S,5'S)-5,5'-((((5,5'-(2,2'-dichloro-[1,1'-biphenyl]-3,3'-diyl)bis(3-methoxypyrazine-5,2-diyl))bis(methylene))bis(azanediyl))bis(methylene))bis(pyrrolidin-2-one) | [Molecular Formula]
C34H36Cl2N8O4 | [MOL File]
2374856-75-2.mol | [Molecular Weight]
691.61 |
| Chemical Properties | Back Directory | [Boiling point ]
817.1±65.0 °C(Predicted) | [density ]
1.310±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 50 mg/mL (72.30 mM; Need ultrasonic) | [form ]
Solid | [pka]
15.81±0.40(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Uses]
Evixapodlin (GS-4224) is a human PD-1/PD-L1 protein/protein interaction inhibitor with an IC50 of 0.213 nM. Evixapodlin has anticancer and antiviral functions[1]. | [in vivo]
Evixapodlin (Compound 139; 10-50 mg/kg; intraperitoneal injection, daily, for 6 days) treatment shows >90% PD-L1 target occupancy (TO) on the tumor cells. Evixapodlin significantly inhibits tumor growth in a human PD-L1 expressing MC38 mouse colorectal tumor model[1]. | Animal Model: | Female C57BL/6 mice injected with MC38 tumor cells[1] | | Dosage: | 10 mg/kg, 25 mg/kg, and 50 mg/kg | | Administration: | Intraperitoneal injection, daily, for 6 days | | Result: | Showed greater than 90% TO on the tumors and inhibited tumor growth in vivo. |
| [References]
[1] Evangelos Aktoudianakis, et al. Pd-1/pd-l1 inhibitors. WO2019160882A1. |
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| Company Name: |
InvivoChem
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| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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