| Identification | Back Directory | [Name]
MEISi-2 | [CAS]
2375595-72-3 | [Synonyms]
4-amino-5-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-7H-thieno[2,3-b]pyridin-6-one | [Molecular Formula]
C19H21ClN6OS | [MOL File]
2375595-72-3.mol | [Molecular Weight]
416.93 |
| Hazard Information | Back Directory | [Uses]
HPK1-IN-2 dihydrochloride is a potent and orally active hematopoietic progenitor kinase-1 (HPK1) inhibitor (IC50<0.05 μΜ) with antitumor activity. HPK1-IN-2 dihydrochloride also inhibits Lck (0.05 μΜ | [in vivo]
HPK1-IN-2 (example A1; 75-150 mg/kg; oral gavage; daily; for 21 days) treatment shows a dose-dependently tumor growth inhibition, with 75 mg/kg and 150 mg/kg QD inhibiting tumour growth by 44% and 64%, respectively[1]. | Animal Model: | Female BALB/c mice (6-8week old) injected with CT26 cancer cells[1] | | Dosage: | 75 mg/kg and 150 mg/kg | | Administration: | Oral gavage; daily; for 21 days | | Result: | Showed a dose-dependently tumor growth inhibition. |
| [References]
[1] Peter Brent Sampson, et al. Hpk1 inhibitors and methods of using same. WO2016205942A1. |
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| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
|