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SH1573 is an orally active mIDH2 inhibitor. SH1573 has a strong and selective inhibitory effect on mIDH2 R140Q protein (IC50=4.78 nmol/L), and can effectively reduce the production of the carcinogenic metabolite 2-hydroxyglutarate (2-HG) in animal models, cell lines, serum and tumors. SH1573 can be used for the study of acute myeloid leukemia (AML)[1]. | [References]
[1] Zhiqiang Wang, et al. "Preclinical efficacy against acute myeloid leukaemia of SH1573, a novel mutant IDH2 inhibitor approved for clinical trials in China." Acta Pharmaceutica Sinica B 11.6 (2021): 1526-1540. DOI:10.1016/j.apsb.2021.03.005 |
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