ChemicalBook--->CAS DataBase List--->2378056-80-3

2378056-80-3

Request For Quotation
2378056-80-3 Structure

2378056-80-3 Structure
IdentificationBack Directory
[Name]

2-Pyrrolidinecarboxamide, 1-[(2R)-2-[3-[4-[[4-[[trans-3-[[4-[3-[3-amino-6-(2-hydroxyphenyl)-4-pyridazinyl]-3,8-diazabicyclo[3.2.1]oct-8-yl]-2-pyridinyl]oxy]cyclobutyl]oxy]-1-piperidinyl]methyl]-1-piperidinyl]-5-isoxazolyl]-3-methyl-1-oxobutyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (2S,4R)-
[CAS]

2378056-80-3
[Synonyms]

2-Pyrrolidinecarboxamide, 1-[(2R)-2-[3-[4-[[4-[[trans-3-[[4-[3-[3-amino-6-(2-hydroxyphenyl)-4-pyridazinyl]-3,8-diazabicyclo[3.2.1]oct-8-yl]-2-pyridinyl]oxy]cyclobutyl]oxy]-1-piperidinyl]methyl]-1-piperidinyl]-5-isoxazolyl]-3-methyl-1-oxobutyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethy...
2-Pyrrolidinecarboxamide, 1-[(2R)-2-[3-[4-[[4-[[trans-3-[[4-[3-[3-amino-6-(2-hydroxyphenyl)-4-pyridazinyl]-3,8-diazabicyclo[3.2.1]oct-8-yl]-2-pyridinyl]oxy]cyclobutyl]oxy]-1-piperidinyl]methyl]-1-piperidinyl]-5-isoxazolyl]-3-methyl-1-oxobutyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (2S,4R)-
[Molecular Formula]

C61H76N12O7S
[MOL File]

2378056-80-3.mol
[Molecular Weight]

1121.4
Chemical PropertiesBack Directory
[density ]

1.40±0.1 g/cm3(Predicted)
[pka]

6.27±0.30(Predicted)
Hazard InformationBack Directory
[Uses]

A947 is a potent and selective SMARCA2 proteolysis-targeting chimera molecule (PROTAC). A947 also is a potent and moderately selective SMARCA2 degrader. A947 has binding affinity to the SMARCA2 bromodomain with a Kd value of 93 nM. A947 can be used for the research of cancer[1].
[in vivo]

A947 (i.v.; 40 mg/kg; single-dose, 2 week or every other week, 30 days) has active in SMARCA4-mutant NSCLC xenograft models in vivo[1].

Animal Model:SMARCA4-mutant NSCLC xenograft models
Dosage:40mg/kg
Administration:Intravenous , single-dose, 2 week; Intravenous , every other week, 30 days
Result:Rapidly reduced the tumor SMARCA2 protein levels and significant decreased the tumor growth.
[References]

[1] Jennifer Cantley, et al. Selective PROTAC-mediated degradation of SMARCA2 is efficacious in SMARCA4 mutant cancers. Nat Commun. 2022 Nov 10;13(1):6814. DOI:10.1038/s41467-022-34562-5
Spectrum DetailBack Directory
[Spectrum Detail]

2-Pyrrolidinecarboxamide, 1-[(2R)-2-[3-[4-[[4-[[trans-3-[[4-[3-[3-amino-6-(2-hydroxyphenyl)-4-pyridazinyl]-3,8-diazabicyclo[3.2.1]oct-8-yl]-2-pyridinyl]oxy]cyclobutyl]oxy]-1-piperidinyl]methyl]-1-piperidinyl]-5-isoxazolyl]-3-methyl-1-oxobutyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (2S,4R)-(2378056-80-3)1HNMR
2378056-80-3 suppliers list
Company Name: Jilin Province Woda Biotechnology Co., Ltd.  
Telephone: 13504435624
Website: https://www.wodapro.com
Company Name: Bide Pharmatech Ltd.  
Telephone: 400-1647117 13681763483
Website: https://www.bidepharm.com/
Company Name: Nantong QuanYi Biotechnology Co., Ltd  
Telephone: 0513-66337626 18051384581
Website: https://www.chemhifuture.com/
Company Name: Xi'an Reinforce Biotechnology Co., Ltd.  
Telephone: 15339237155 15339237155
Website: www.xianqhbio.com
Company Name: Beijing RuiDaHengHui Science&Technology Development Co., LTD  
Telephone: 010-64126590-807 13031133168
Website: www.henghuimall.com/articles/305.html
Tags:2378056-80-3 Related Product Information
2892523-74-7 2892523-73-6 2755761-78-3 2378056-80-3 25316-40-9