| Identification | Back Directory | [Name]
Thalidomide-O-PEG4-azide | [CAS]
2380318-57-8 | [Synonyms]
Thalidomide-O-PEG4-azide
4-((14-azido-3,6,9,12-tetraoxatetradecyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione | [Molecular Formula]
C23H29N5O9 | [MDL Number]
MFCD32207018 | [MOL File]
2380318-57-8.mol | [Molecular Weight]
519.51 |
| Hazard Information | Back Directory | [Description]
Thalidomide-O-PEG4-Azide is a PROTAC linker that is reactive with alkyne or DBCO, BCN attached molecule via click chemistry | [Uses]
Thalidomide-O-PEG4-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-O-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
Cereblon | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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