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2401832-00-4

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2401832-00-4 Structure

2401832-00-4 Structure
IdentificationBack Directory
[Name]

Thalidomide-O-PEG4-amine
[CAS]

2401832-00-4
[Synonyms]

Thalidomide-O-PEG4-NH2
Thalidomide-O-PEG4-amine
4-((14-amino-3,6,9,12-tetraoxatetradecyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
[Molecular Formula]

C23H31N3O9
[MDL Number]

MFCD32670308
[MOL File]

2401832-00-4.mol
[Molecular Weight]

493.51
Chemical PropertiesBack Directory
[Boiling point ]

690.9±55.0 °C(Predicted)
[density ]

1.321±0.06 g/cm3(Predicted)
[pka]

10.70±0.40(Predicted)
Safety DataBack Directory
[HS Code ]

2933998090
Hazard InformationBack Directory
[Description]

Thalidomide-O-PEG4-Amine is synthesized compound that can react with NHS ester group or carboxylic acid in the presence of EDC or HATU
[Uses]

Thalidomide-O-PEG4-amine is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
[IC 50]

Cereblon
[References]

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
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