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2387738-43-2

2387738-43-2 Structure

2387738-43-2 Structure
IdentificationBack Directory
[Name]

INDEX NAME NOT YET ASSIGNED
[CAS]

2387738-43-2
[Synonyms]

Mal-amide-PEG8-Val-Cit-PAB-OH
[Molecular Formula]

C44H71N7O16
[MOL File]

2387738-43-2.mol
[Molecular Weight]

954.07
Chemical PropertiesBack Directory
[Boiling point ]

1120.5±65.0 °C(Predicted)
[density ]

1.239±0.06 g/cm3(Predicted)
[pka]

13.41±0.70(Predicted)
Hazard InformationBack Directory
[Uses]

Mal-amide-PEG8-Val-Cit-PAB-OH is a cleavable ADC linker featuring a maleimide, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB functional group. Maleimide is used to covalently bind free thiols on the cysteine residues of proteins. The Val-Cit dipeptide is cleaved by cellular proteases within the cell to allow for efficient payload delivery with the help of the PAB structure.
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