| Identification | Back Directory | [Name]
IACS-15414 | [CAS]
2411321-29-2 | [Synonyms]
IACS-15414
4(3H)-Pyrimidinone, 6-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]dec-8-yl]-3-(2,3-dichlorophenyl)-2-methyl- | [Molecular Formula]
C20H24Cl2N4O2 | [MOL File]
2411321-29-2.mol | [Molecular Weight]
423.34 |
| Chemical Properties | Back Directory | [Boiling point ]
566.2±60.0 °C(Predicted) | [density ]
1.46±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
9.53±0.40(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Uses]
IACS-15414 is a potent and orally bioavailable SHP2 inhibitor with an IC50 value of 122 nM. | [References]
[1] Czako B, et al. Discovery of 6-[(3S,4S)-4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methyl-3,4-dihydropyrimidin-4-one (IACS-15414), a Potent and Orally Bioavailable SHP2 Inhibitor. J Med Chem. 2021 Oct 28;64(20):15141-15169. DOI:10.1021/acs.jmedchem.1c01132 |
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