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2413716-15-9

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2413716-15-9 Structure

2413716-15-9 Structure
IdentificationBack Directory
[Name]

TCMDC-135051
[CAS]

2413716-15-9
[Synonyms]

TCMDC-135051
TCMDC-135051 HCl
Benzoic acid, 4-[2-[5-[(diethylamino)methyl]-2-methoxyphenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-2-(1-methylethyl)-
[Molecular Formula]

C29H33N3O3
[MDL Number]

MFCD32201098
[MOL File]

2413716-15-9.mol
[Molecular Weight]

471.59
Chemical PropertiesBack Directory
[density ]

1.173±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO: 250 mg/mL (530.12 mM)
[form ]

Solid
[pka]

3.10±0.10(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

TCMDC-135051 is a highly selective and potent protein kinase PfCLK3 inhibitor with low off-target toxicity. TCMDC-135051 prevents trophozoite-to-schizont transition, disrupts transcription and reduces transmission to the mosquito vector. TCMDC-135051 has antiparasiticidal activity (EC50=320 nM)[1].
[storage]

Store at -20°C
[References]

[1] Alam MM, et al. Validation of the protein kinase PfCLK3 as a multistage cross-species malarial drug target. Science. 2019 Aug 30;365(6456). pii: eaau1682. DOI:10.1126/science.aau1682
Spectrum DetailBack Directory
[Spectrum Detail]

TCMDC-135051(2413716-15-9)1HNMR
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