| Identification | Back Directory | [Name]
TCMDC-135051 | [CAS]
2413716-15-9 | [Synonyms]
TCMDC-135051
TCMDC-135051 HCl
Benzoic acid, 4-[2-[5-[(diethylamino)methyl]-2-methoxyphenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-2-(1-methylethyl)- | [Molecular Formula]
C29H33N3O3 | [MDL Number]
MFCD32201098 | [MOL File]
2413716-15-9.mol | [Molecular Weight]
471.59 |
| Chemical Properties | Back Directory | [density ]
1.173±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 250 mg/mL (530.12 mM) | [form ]
Solid | [pka]
3.10±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
TCMDC-135051 is a highly selective and potent protein kinase PfCLK3 inhibitor with low off-target toxicity. TCMDC-135051 prevents trophozoite-to-schizont transition, disrupts transcription and reduces transmission to the mosquito vector. TCMDC-135051 has antiparasiticidal activity (EC50=320 nM)[1]. | [storage]
Store at -20°C | [References]
[1] Alam MM, et al. Validation of the protein kinase PfCLK3 as a multistage cross-species malarial drug target. Science. 2019 Aug 30;365(6456). pii: eaau1682. DOI:10.1126/science.aau1682 |
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