| Identification | Back Directory | [Name]
2-Pyridinecarboxamide, 4-[4-[[trans-4-[[5-(trifluoromethyl)-2-pyridinyl]amino]cyclohexyl]sulfonyl]phenyl]- | [CAS]
2437547-04-9 | [Synonyms]
2-Pyridinecarboxamide, 4-[4-[[trans-4-[[5-(trifluoromethyl)-2-pyridinyl]amino]cyclohexyl]sulfonyl]phenyl]- | [Molecular Formula]
C24H23F3N4O3S | [MDL Number]
MFCD32693866 | [MOL File]
2437547-04-9.mol | [Molecular Weight]
504.52 |
| Chemical Properties | Back Directory | [Boiling point ]
705.4±60.0 °C(Predicted) | [density ]
1.391±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 125 mg/mL (247.76 mM) | [form ]
Solid | [pka]
14.71±0.50(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
CCR6 inhibitor 1 is a potent and selective CCR6 inhibitor, with IC50s of 0.45 and 6 nM for monkey and human CCR6, much more selective at CCR6 over human CCR1 (IC50, > 30000 nM), and CCR7 (IC50, 9400 nM). CCR6 inhibitor 1 markedly blocks ERK phosphorylation. CCR6 inhibitor 1 is used in the research of autoimmune diseases and cancer[1]. | [IC 50]
Moneky CCR6: 0.45 nM (IC50); Human CCR6: 6 nM (IC50); Human CCR7: 9400 nM (IC50) | [storage]
Store at -20°C | [References]
[1] Tawaraishi T, et al. Identification of a novel series of potent and selective CCR6 inhibitors as biological probes. Bioorg Med Chem Lett. 2018 Oct 1;28(18):3067-3072. DOI:10.1016/j.bmcl.2018.07.042 |
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