| Identification | Back Directory | [Name]
PALMITOYL GLYCINE | [CAS]
2441-41-0 | [Synonyms]
PalGly
Palmtoyl Glycine
N-palmitoylglycine
N-Palmitoylglycine D31
2-palMitaMidoacetic acid
PalGly >=98% (HPLC), solid
Hexadecanoylaminoacetic acid
Palmitoyl-glycine≥ 99% (TLC)
Glycine, N-(1-oxohexadecyl)-
2-(hexadecanoylamino)aceticaci
2-(hexadecanoylamino)acetic acid
N-PALMITOYLGLYCINE;N-PALMITOYLGLYCINE | [EINECS(EC#)]
627-023-4 | [Molecular Formula]
C18H35NO3 | [MDL Number]
MFCD00153471 | [MOL File]
2441-41-0.mol | [Molecular Weight]
313.48 |
| Chemical Properties | Back Directory | [Melting point ]
121 °C(Solv: acetone (67-64-1)) | [Boiling point ]
491.8±28.0 °C(Predicted) | [density ]
0.960±0.06 g/cm3(Predicted) | [vapor pressure ]
0.001Pa at 85℃ | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMSO: >10mg/mL | [form ]
solid | [pka]
3.59±0.10(Predicted) | [color ]
white to off-white | [Cosmetics Ingredients Functions]
CLEANSING
HAIR CONDITIONING | [InChI]
InChI=1S/C18H35NO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-17(20)19-16-18(21)22/h2-16H2,1H3,(H,19,20)(H,21,22) | [InChIKey]
KVTFEOAKFFQCCX-UHFFFAOYSA-N | [SMILES]
C(O)(=O)CNC(=O)CCCCCCCCCCCCCCC | [LogP]
5.85 at 25℃ |
| Hazard Information | Back Directory | [Chemical Properties]
White to off-white powder | [Uses]
N-palmitoylglycine has been used as an intact polar lipid (IPL) standard for determination of δ 15N values of nitrogen containing headgroups of IPLs using gas chromatography/combustion/isotope-ratio mass spectrometry. | [Definition]
ChEBI: N-hexadecanoylglycine is an N-acylglycine in which the acyl group is specified as hexadecanoyl (palmitoyl). It has a role as a marine metabolite and a human metabolite. It is a fatty amide and a N-acylglycine 16:0. It is functionally related to a hexadecanoic acid. It is a conjugate acid of a N-hexadecanoylglycinate. | [Biological Activity]
PalGly is an endogenous signaling lipid th at modulates calcium influx and nitric oxide production. PalGly inhibits heat-evoked firing of wide dynamic range (WDR) neuronsactivates calcium influx in DRG cells and stimulates NO production. Preliminary studies suggest its signaling mechanism involves GPCR-mediated cation channel activation and a Gαi/o-coupled signaling pathwaywhich is being further investigated. | [in vivo]
Palmitoylglycine potently inhibits heat-evoked firing of nociceptive neurons in rat dorsal horn[3].
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