2446474-06-0

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2446474-06-0 Structure

Identification	Back Directory
[Name] Pomalidomide 4'-alkylC8-amine
[CAS] 2446474-06-0
[Synonyms] Thalidomide-NH-C8-NH2 HCl Pomalidomide 4'-alkylC8-amine Pomalidomide-C8-NH2 hydrochloride
[Molecular Formula] C21H29ClN4O4
[MDL Number] MFCD31729300
[MOL File] 2446474-06-0.mol
[Molecular Weight] 436.94

Hazard Information	Back Directory
[Uses] Thalidomide-NH-C8-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].
[Biological Activity] Pomalidomide 4'-alkylC8-amine is a functionalized cereblon ligand for PROTAC? research and development; incorporates an E3 ligase ligand plus an alkylC8 linker with terminal amine ready for conjugation to a target protein ligand.
[IC 50] Cereblon
[storage] Store at -20°C
[References] [1] Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine.?Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. DOI:10.3389/fcell.2021.629326 [2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277

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