| Identification | Back Directory | [Name]
4-Quinolinamine, 6-methoxy-2-(5-methyl-2-furanyl)-N-[(1-methyl-4-piperidinyl)methyl]-7-[3-(1-pyrrolidinyl)propoxy]-, hydrochloride (1:3) | [CAS]
2448471-08-5 | [Synonyms]
4-Quinolinamine, 6-methoxy-2-(5-methyl-2-furanyl)-N-[(1-methyl-4-piperidinyl)methyl]-7-[3-(1-pyrrolidinyl)propoxy]-, hydrochloride (1:3) |
| Hazard Information | Back Directory | [Uses]
CM-579 trihydrochloride is a first-in-class reversible, dual inhibitor of G9a and DNMT, with IC50 values of 16 nM, 32 nM for G9a and DNMT, respectively. Has potent in vitro cellular activity in a wide range of cancer cells[1]. | [IC 50]
DNA Methyltransferase: 32 nM (IC50); DNMT1: 1.5 nM (Kd); DNMT3A: 92 nM (IC50); DNMT3B: 1000 nM (IC50); G9a: 16 nM (IC50) | [References]
[1] San José-Enériz E, et al. Discovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs in hematological malignancies. Nat Commun. 2017 May 26;8:15424. DOI:10.1038/ncomms15424 |
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