| Identification | More | [Name]
TERPIN MONOHYDRATE | [CAS]
2451-01-6 | [Synonyms]
1,8-MENTHANEDIOL HYDRATE
CIS-P-MENTHANE-1,8-DIOL MONOHYDRATE
DIPENTENEGLYCOL
P-MENTHANE-1,8-DIOL, HYDRATE
P-MENTHANE-1,8-DIOL, MONOHYDRATE
TERPIN HYDRATE
TERPIN HYDRATE, MONOHYDRATE
TERPIN MONOHYDRATE
TERPINOL HYDRATE
Terpinhydratecryst.
TerpineHydrateBp
Cyclohexanemethanol, 4-hydroxy-.alpha.,.alpha.,4-trimethyl-, monohydrate, cis-
cis-p-menthane-1,8-diol
trans-4-(1-hydroxy-1-methylethyl)-1-methylcyclohexan-1-ol
cis-1,8-p-Menthanediol monohydrate, 98%
(Z)-1,8-methandiol hydrate
cis-Terpin hydrate | [EINECS(EC#)]
209-279-5 | [Molecular Formula]
C10H22O3 | [MDL Number]
MFCD00167312 | [Molecular Weight]
190.28 | [MOL File]
2451-01-6.mol |
| Chemical Properties | Back Directory | [Appearance]
Colorless, lustrous, rhombic, crystalline
prisms or white powder; slight characteristic odor;
slightly bitter taste. Efflorescent. Soluble in alcohol
and ether; slightly soluble in water. Combustible. | [Melting point ]
116-117°C | [Boiling point ]
bp 258° | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
White to Off-White | [Water Solubility ]
3.42g/L(25 ºC) | [Merck ]
9169 | [Major Application]
pharmaceutical (small molecule) | [InChI]
1S/C10H20O2.H2O/c1-9(2,11)8-4-6-10(3,12)7-5-8;/h8,11-12H,4-7H2,1-3H3;1H2/t8-,10+; | [InChIKey]
JGKJMBOJWVAMIJ-OFAZAQPOSA-N | [SMILES]
O.CC(C)(O)[C@@H]1CC[C@](C)(O)CC1 | [CAS DataBase Reference]
2451-01-6(CAS DataBase Reference) |
| Safety Data | Back Directory | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RIDADR ]
UN 3265 8 / PGII | [WGK Germany ]
3
| [TSCA ]
Yes | [HS Code ]
2906195000 | [Storage Class]
11 - Combustible Solids |
| Hazard Information | Back Directory | [Chemical Properties]
Colorless, lustrous, rhombic, crystalline
prisms or white powder; slight characteristic odor;
slightly bitter taste. Efflorescent. Soluble in alcohol
and ether; slightly soluble in water. Combustible. | [Uses]
Used in screening of essential oil from Artemisia scoparia leaves for free radical scavenging activity | [Uses]
Pharmaceuticals, source of terpineol, medicine
(expectorant). | [Synthesis]
Terpin monohydrate is prepared from alpha-Pinene or Turpentine oil
by treatment with dilute sulfuric acid.
It has also been manufactured in the U.S.A.
from Pine Oil by acid treatment. | [in vivo]
Terpin hydrate (50 mg/kg, ig, once daily for 2-3 days) inhibits the increase in pulmonary resistance and decrease in pulmonary surfactant activity in Paraquat dichloride (HY-B0864A)-administrated rats models[1]. | Animal Model: | Paraquat dichloride (HY-B0864A)-administrated wistar rat models[1] | | Dosage: | 50 mg/kg | | Administration: | intragastric administration, once daily for 2-3 days | | Result: | Increased the pulmonary resistance and decreased the pulmonary surfactant activity. |
| [storage]
Store at -20°C | [Purification Methods]
Crystallise terpin from H2O or EtOH. The anhydrous cis-isomer distils at 258o/760mm but hydrates on exposure to moist air. Anhydrous terpin is also obtained by recrystallisation from absolute EtOH. [Sword J Chem Soc 127 1632 1925, Lombard & Ambrose Bull Soc Chim Fr 230 1961, Beilstein 5 IV 435.] |
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