| Identification | Back Directory | [Name]
2-Propenamide, 3-(4-fluorophenyl)-N-(2-oxo-2H-1-benzopyran-6-yl)-, (2E)- | [CAS]
2451479-57-3 | [Synonyms]
hCAIX-IN-5
2-Propenamide, 3-(4-fluorophenyl)-N-(2-oxo-2H-1-benzopyran-6-yl)-, (2E)- | [Molecular Formula]
C18H12FNO3 | [MOL File]
2451479-57-3.mol | [Molecular Weight]
309.29 |
| Hazard Information | Back Directory | [Uses]
hCAIX-IN-5 (compound 6b) is a potent and selective hCAIX inhibitor with KIs of >10000, >10000, 130.7, 829.1 nM for hCAI, hCAII, hCAIV, hCAIX, respectively[1]. | [References]
[1] Swain B, et al. New coumarin/sulfocoumarin linked phenylacrylamides as selective transmembrane carbonic anhydrase inhibitors: Synthesis and in-vitro biological evaluation. Bioorg Med Chem. 2020 Aug 1;28(15):115586. DOI:10.1016/j.bmc.2020.115586 |
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