| Identification | Back Directory | [Name]
IL-17A inhibitor 1 | [CAS]
2452464-73-0 | [Synonyms]
LY-3533028
IL-17A inhibitor 1
1,2,5-Oxadiazole-3-carboxamide, N-[(S)-(4,4-difluorocyclohexyl)[7-[(1S)-2-methoxy-1-[(4S)-2-oxo-4-(trifluoromethyl)-1-imidazolidinyl]ethyl]imidazo[1,2-b]pyridazin-2-yl]methyl]-4-methyl- | [Molecular Formula]
C24H27F5N8O4 | [MDL Number]
MFCD34474218 | [MOL File]
2452464-73-0.mol | [Molecular Weight]
586.51 |
| Chemical Properties | Back Directory | [density ]
1?+-.0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
11.52±0.46(Predicted) | [color ]
Off-white to yellow | [InChIKey]
MVWVCLAORBNXSD-UWVAXJGDSA-N | [SMILES]
O1N=C(C)C(C(N[C@@H](C2CCC(F)(F)CC2)C2=CN3C(=N2)C=C([C@H](N2C(=O)N[C@H](C(F)(F)F)C2)COC)C=N3)=O)=N1 |
| Hazard Information | Back Directory | [Uses]
LY3509754 (IL-17A inhibitor 1) is a IL-17A inhibitor, with IC50 values of <9.45 nM and 9.3 nM in alphalisa assay and HT-29 cells[1]. | [Biological Activity]
IL-17A inhibitor 1 (example 24) is a IL-17A inhibitor, with IC50 values of <9.45 nM and 9.3 nM in alphalisa assay and HT-29 cells[1].
IL-17A inhibitor 1 (example 24) possesses high oral bioavailability (F=107%)[1]. | [in vivo]
LY3509754 (example 24) possesses high oral bioavailability (F=107%)[1]. | [IC 50]
IL-17 | [storage]
Store at -20°C | [References]
[1]. COATES DAVID ANDREW, et al. IMIDAZO[1,2-B]PYRIDAZINE IL-17A INHIBITORS. Patent WO2020146194. |
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