| Identification | Back Directory | [Name]
Pyr6 | [CAS]
245747-08-4 | [Synonyms]
Pyr6
Pyr6 >=98% (HPLC)
N-{4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}-3-fluoroisonicotinamide
N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-3-fluoro-4-pyridinecarboxamide
4-Pyridinecarboxamide, N-[4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-3-fluoro- | [Molecular Formula]
C17H9F7N4O | [MDL Number]
MFCD28385867 | [MOL File]
245747-08-4.mol | [Molecular Weight]
418.27 |
| Chemical Properties | Back Directory | [Melting point ]
162-163 °C | [Boiling point ]
368.4±42.0 °C(Predicted) | [density ]
1.52±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 100 mg/mL (239.08 mM) | [form ]
Solid | [pka]
9.85±0.70(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Pyr6 is a selective store operated calcium entry (SOCE) inhibitor with an IC50 of 0.49 μM. Pyr6 displays 37-fold higher potency for RBL SOCE than for TRPC3 ROCE[1]. | [Biological Activity]
Pyr6 is a selective inhibitor of calcium release from the endoplasmic reticulum via STIM1/Orai1 mediatedstore operated calcium entry (SOCE). Pyr6 blocks SOCE in thapsigargin treatedcalcium depleted BRL-2H3 cells (IC50 = 0.49 μM)but has poor activity against carbachol-inducedTRPC3-mediated calcium entry in TRPC3-transfected HEK293 cells (IC50 = 18.46 μM). | [storage]
Store at -20°C | [References]
[1] Schleifer H, et al. Novel pyrazole compounds for pharmacological discrimination between receptor-operated and store-operated Ca(2+) entry pathways. Br J Pharmacol. 2012 Dec;167(8):1712-22. DOI:10.1111/j.1476-5381.2012.02126.x |
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Musechem
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DC Chemicals
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